Flashcards in Acid/Base Disorders Deck (36):
Describe normal arterial blood gases (ABG's)
PH: 7.35-7.45 (7.4)
PaCO2: 35-45 (40)
PaO2: 80-100 (90)
HCO3: 22-26 (24)
O2 Sat: 92-100%
What should you get to completely evaluate acid base states?
Basic metabolic panel
What is important about hypoxemia?
Subnormal oxygenation in blood
Normal O2 = 104-.27 x age = 100-1/3 x age = decreases with age
What are cause of hypoxia?
Ventilation/Perfusion mismatch as seen in pulmonary embolus
Shunting, eg cardiac abnormalities
Low inspired fraction of O2 (FiO2)
Diffusion abnormalities, eg alveolar hemorrhage, connective tissue disorder
Describe ABG terms
When does kidney start to retain HCO3?
In 12-16 hrs
Max conc in 1 week
What is the 3 step approach to ABG analysis?
1. Does patient have acidosis or alkalosis? pH high or low?
2. Is acidosis/alkalosis a respiratory or metabolic process?
3. If it is a respiratory acidosis/alkalosis, is it a pure respiratory process, or is there a metabolic component?
How do you determine respiratory vs metabolic acidosis/alkalosis?
If pH and pCO2 are both increased or decreased in same direction, then the process is metabolic
If one is increased, while the other is decreased (opposite), the process is respiratory
-as pCO2 increases, then pH decreases
Describe the change in a pure respiratory process of acidoss/alkalosis
For each 10 mmHg change in PaCo2, the pH should move in opposite direction by 0.08 (+/- 0.02)
If PaCO2 is 30, what should the pH be?
If PaCo2 is 60, what should the pH be?
A decrease of 10 mmHg from 40 will lead to pH of 7.48 (7.4+0.08)
An increase of 20 mmHg from 40 will lead to pH of 7.24 (7.4-(2x0.08)), a decrease of 0.16, or 0.08 for each 10 mmHg rise in pCO2
Describe the mixed process of acidosis/alkalosis
Step 3 of ABG analysis compares the "should be" (expected/calculated) pH to actual measured pH
If actual pH is not what it should be, is it higher or lower?
If higher, there must be a concomitant metabolic alkalosis
If lower, there must be a concomitant metabolic acidosis
70 y/o M presents to ED with increasing dyspnea (RR 25 breaths/min)
PE: JVD at 45 degrees, estimated CVP 11mm H2O
Lungs: b/l crackles in bases and scattered wheezes
Heart: grade 3/6 systolic murmur at apex with radiation into left axilla, S3 gallop heard, no S4
B/l peripheral edema of legs. Cool extremities
BP 100/68, P 115/min, afebrile, O2 sat 78%
1. What is his anion gap?
2. What is his diagnosis?
3. What other tests would you use?
4. How would you treat this pt?
1. Na - (Cl + HCO3)
128 - (92+12)
2. Metabolic acidosis with high anion gap
Atrial fibrillation with rapid ventricular response
3. Echocardiogram, lactic acid level, cardiac enzymes (troponin I, CK MB)
4. Oxygen 2-4 L/min N/C
IV - loop diuretic
Fluid restriction 1-1.5 L/day
Na HCO3 - cautiously
ACEI - cautiosly
What are normal electrolytes values?
Na 135-145 (140)
K 3.5-5 (4)
Cl 98-106 (103)
CO2 21-28 (24)
What is the anion gap?
Na-(Cl + HCO3)
Reflects concentration of anions that are not routinely measured (sulfates, phosphates, acetoacetic acid, beta hydroxybutyric acid)
Describe metabolic acidosis
Decrease in extracellular pH caused by a decrease in HCO3
1. Loss of HCO3: GI tract, renal
2. Increase hydrogen load: DKA or lactic
3. Decrease hydrogen excretion by kidney: uremic acidosis or RTA
Elevated anion gap
Normal anion gap with hyperchloremia
What are causes of high anion gap?
High anion gap, metabolic acidosis: MUDPILES
Methanol: formic A
Uremia (renal failure)
-increased BUN, Cr
-increased sulfates, phosphates as unmeasured anions
-increased glucose. Starvation, alcohol abuse
-acetoacetic acid, B-hydroxybutyric acid
-shock, sepsis, low perfusion, marathon runners
Ethylene glycol, glycolic
-CO, cyanide, alcohol, toluene
Describe lactic acidosis
Type A (tissue hypoxia)
-shock, severe anemia, heart failure, CO poisoning
Type B1 (associated with systemic disorders)
-DM, liver failure, sepsis, seizures
Type B2 (associated with drugs/toxins)
-ethanol, methanol, ethylene glycol, ASA
Type B3 (associated with inborn errors of metabolism)
68 y/o F presents to ED in lethargic state. Past 3-4 weeks, anorexia, confusion, edema, and weight gain.
PMH positive for poorly controlled HTN and diabetes mellitus, DJD, and hypothyroidis
Meds: HCTZ 50 mg daily, Lantus insulin 20 units hs, NSAID for arthritis, and synthyroid 0.05 mg orally daily
Arousable but lethargic
BP 158/88, P 90/min, R 10 breaths/min, temp 98F, O2 sat 88%
Neck veins mildly distended at 45
Heart: 2/6 systolic murmur 2nd ICS, RSB with slight radiation into R carotid
Lungs: basilar crackles, R>L
Abdomen: tenderness RUQ, edge of liver is 3 fingers below costal margin. Percussion span of liver is 8 cm (normal)
Extremities: marked pitting edema of feet, calves, and thighs
1. What is your diagnosis?
2. Differential diagnosis?
3. What tests do you order?
4. PH 7.1, pCO2 45, pO2 68, HCO3 8. Analysis?
5. Na 150, K 7, Cl 115, HCO3 10. Anion gap?
7. How would you treat the pt?
1. Metabolic encephalopathy: R/O hypothyroid (myxedema)
Likely ischemic cerebral vascular disease due to poorly controlled hypertension
Ischemic cerebral vascular disease
Valvular heart disease
3. CBC: Hgb 9 g, Hct 27%
4. Metabolic and respiratory acidosis
5. 150 - (115+10) = 25
6. High anion gap metabolic acidosis because of renal failure (retention of hydrogen ions) in uremic acidosis
And respiratory acidosis: lungs haven't compensated as you'd expect for metabolic acidosis by decreasing pCO2
7. Dialysis: hemodialysis
Aerosol treatments with nebulizers
37 y/o F presents to ED with 6 day history of diarrhea. Approximately 7 stools/day and up 3-4 times through night with watery, non-bloody stools. Able to drink fluids, soups, jello. Hasn't traveled out of country, camped outdoors, or ingested spring/river water. Aunt has Crohn's disease. No antibiotics over past 4 months.
BP 80/50, P 110/min, R 18/min, Temp 100F, O2 Sat 94
General: pale, poor skin turgor, dry mucous membranes
Neck veins flat
Heart: no murmur, S3 or S4.Tachycardia 110 p/min
Abdomen: hyperactive bowel sounds, mildly tender diffusely, no organomegaly
Extremities: coo to touch. Tattoo R ankle
1. Diagnosis/differential diagnosis?
2. CBC Hb16, Hct 50%, WBC 14,000
CMP: Na 148, K 2.6, Cl 114, HCO3 20
Stools: culture for enteric pathogens, ova parasites, WBC's/hemoccult of stool
ABG: pH 7.1, pCO2 34, pO2 92, HCO3 20
3. ABG analysis?
1. Diarrhea: secretory, infectious, consider inflammatory bowel disease
Hypovolemia: volume contracted, possible electrolyte/acid base disturbance
2. 148 - (114+20) = 14 (normal)
3. Metabolic acidosis (normal anion gap, low HCO3, elevated Cl)
4. IV fluids for volume restoration (careful not to give too much NaCl or N/S)
Could give fluids of 1/2 strength N/S with Na HCO3 and K
What are causes of normal anion gap metabolic acidosis (HCO3 falls and Cl rises. hyperchloremic met acid)?
Acid infusion, acetazolamide
Renal tubular acidosis
-Renal loss of HCO3 or decreased H sec
-losing HCO3, decreases K
Ureteral sigmoid or ileal diversion
-losing HCO3/increasing Cl and H resorption
-losing HCO3, decreased K
Describe distal renal tubular acidosis
Decreased secretion of H, so not getting rid of acid, ie failure to acidify urine
Possible causes: SLE, Sjogren's, toluene
Describe proximal renal tubular acidosis
Decreased absorption of HCO3, so not absorbing buffer
Possible causes: multiple myeloma, heavy metal poisoning, Wilson's disease, amyloidosis
Describe hyperkalemic renal tubular acidosis
Hyporenin and hypoaldosterone
Decreased NH4 excretion and decreased HCO3 production
Possible causes: analgesic nephropathy, sickle cell disease, and SLE
Describe treatment of metabolic acidosis
Rx underlying cause
Rx of CV compromise; pH
46 y/o M presents to your office with weakness and one week history of vomiting. Not able to even drink water, tea, or soup without vomiting. Hasn't eaten any solid food for past 6 days. Denied diarrhea or hematemesis. Admits to chills, malaise, and felt hot. PMH unremarkable. No meds or allergies.
BP 90/52, P 118/min, R 20/min, 101F, O2 Sat 90%
General appearance: dry mucous membranes, poor skin turgor with mild tenting
Neck veins flat
Heart: no murmur, S3 or S4. Normal S1 and S2 splits on inspiration
Abdomen: vitiligo areas on abdomen, no distention or organomegaly
Extremities: no edema, normal temperature to touch, no rashes
1. Diagnosis/differential diagnosis?
2. CBC, Hb 16.5, Hct 49%, WBC 11,500
CMP Na 130, Cl 88, K 3.0, HCO3 31
Urine Cl 10 mEq/L
Stool hemoccult negative
Blood cultures pending
ABG: pH 7.5, pCO2 45, pO2 90, HCO3 31
3. How would you treat this pt?
1. Vomiting complicated by volume contraction
Hypotension, tachycardia secondary volume loss
Fever: R/O intestinal infection
2. Metabolic alkalosis (due to vomiting with contraction alkalosis: volume loss)
3. IV fluids (0.9% N/S with KCL) to replenish volume loss and dehydration
Describe metabolic alkalosis
Increase pH, big increase HCO3, increase paCO2
Compensate paCO2 increase 0.7 for every 1 increase in HCO3
PaCO2=0.9xHCO3 +9 (+/-2)
Causes: CLEVER PD
Cl loss of HCO3 excess
Cl loss: vomiting , N/G suction, villous adenoma, diuretics
HCO3 excess: enhanced HCO3 resorption (hyperaldo, licorice excess)
What are causes of metabolic alkalosis?
Contraction of volume
Endocrine (Conns, Cushing's, Bartters)
Describe metabolic alkalosis: Cl responsive
Describe metabolic alkalosis: Cl unresponsive
Urine Cl> 10-20 mEq/L
Unresponsive to saline
Endocrine causes: Bartters, severe K depletion, hyperaldo, Cushing's
Describe treatment for metabolic alkalosis
Rx underlying cause
NaCl, KCl, Magnesium
Spironolactone for mineralocorticoid excess
52 y/o F presents to office with CC of feeling weak all over. Has had this complaint on other visits. Being treated for HTN, but her BP has been more resistant to control despite medications. Meds: beta-blocker, ACEI, and vasodilator. She does not smoke or take hormones or use NSAIDs. She drinks 1-2 glasses of wine every 2-3 weeks
BP 168/104, P 84/min, R 14/min, 98.6, O2 sat 94%
Diffuse muscle weakness in hands, arms, and legs
1. Differential diagnosis?
2. CMP: Na 140, K 2.7, Cl 102, HCO3 30.
Mg, Ca normal. BUN 20, Cr 1.
CBC and TSH normal
3. Urine Cl high>20
Aldosterone level high
Plasma renin level low
1. Diffuse muscle weakness
-Electrolyte disorder. Low levels of Na, K, Mg, Ca
HTN becoming resistant to treatment
2. Metabolic alkalosis
3. Combination of HTN, hypokalemia
Hyperaldosteronism (Conn's syndrome)
4. CT of adrenals
Adenoma (solitary) 85% laparoscopic excision
bilateral hyperplasia (15%): spironolactone to inhibit hyperplasia and aldosterone production (mineralocorticoid excess)
Describe Conn's syndrome
Saline resistant (UCL>20)
Increased HCO3 excretion in urine
74 y/o M presents to ED with dyspnea, cough, and fever. Onset was 6 days ago. Cough is productive of yellowish-greenish sputum. Dyspnea is at rest and on any exertional activity. Temp has been up to 101F with shaking chills
PMH: COPD, oxygen dependent, DJD, and IBS. Smokes 1/2 ppd of cigarettes
Meds: Spiriva inhaler 2 puffs daily, symbicort MDI 2 puff BID, aerosol nebulizer with albuterol with N/S 3-4x/day and prednisone 20 mg po daily for past 6 months
General: respiratory distress, using accessory muscles of respiration. 26-28 breaths/min and shallow, lips are pursed
BP 110/70, P 120 irregular/min, R 28/min, temp 101F, O2 sat 70% (on ambient/room air)
Neck veins distended
Lungs: decreased breath sounds bilaterally with suspected crackles left lung lower lobe
Heart: irregular rhythm, rapid rate (120/min), no murmur
Abdomen: thin, no organomegaly, decreased bowel sounds, non-distended, scar RLQ
Extremities: nicotine stain on fingers. Feet cold with bluish colored toes, no pulses in either foot palpable
Neuro: brisk reflexes arms and legs
No cranial nerve deficit. Alert and oriented
2. CXR, ECG
CBC: WBC 17,500, Hb 12, Hct 36
CMP: Na 130, K 3.8, Cl 102 HCO3 29, BUN 54, creatinine 1.4
Sputum: epithelial cells, no WBC's
Blood cultures pending
ABG: pH 7.14, pCO2 70, pO2 50, HCO3 29
1. Probable pneumonia, CAP (community acquired pneumonia): immunosuppressed due to chronic steroid use
Exacerbation of COPD secondary to infection
Peripheral Vascular Disease secondary to Arterial Sclerosis Obliterans (PVD 2nd ASO)
2. Respiratory acidosis (acute) with hypoxia
3. Admit to ICU, cardiac monitor, and continuous oximetry
Aerosol treatments every 4h around clock (beta agonists, inhaled steroids)
Nasal and oral tracheal suction prn
If airway compromised or gases worsen, BiPAP or CPAP, may need intubation and mechanical ventilation
IV steroids: methylprednisolone 125 mg IV
Sputum for gram stain and C&S
Begin IV antibiotic with coverage against community acquired pathogens
Describe respiratory acidosis and hypoxia
Decrease pH, big increase paCO2, increase HCO3
Anything that causes hypoventilation CNS depression:
-Drugs, CVA, neuromuscular airway obstruction, pneumonia, pulmonary edema, pneumothorax, pleural disease, COPD, restrictive disease (disorders of chest wall, respiratory muscles)
21 y/o F college student presents to ED with a history of right flank pain, fever, chills, and dyspnea. She has a biochemistry test in the morning. No significant PMH.
BP 100/68, P 110/min, R 28/min, temp 100F, O2 sat 89%
Neck: thyroid enlarged, nontender, no JVD
Heart: no murmur, S3 or S4. Soft 1/6 systolic murmur over apex
Abdomen: soft, no guarding or rigidity. Decreased bowel sounds. Tenderness to light percussion/palpation over right costovertebral angel (right flank)
Extremities: warm but no rash
Neurologic: brisk DTRs (+2/4) b/l, slight tremor of hands
2. Differential diagnosis?
3. CBC: Hb 15, Hct 45, WBC 21,000: infection
Blood cultures pending
TSH decreased, free T4 increased
UA: TNTC WBC's in urine, cloudy, and nitrate positive
Renal ultrasound: L kidney normal. R kidney mildly enlarged
ABG: pH 7.56, pCO2 20, pO2 89, HCO3 20
4. Why is she breathing so fast?
1. Probably UTI (pyelonephritis)
2. Sepsis, renal abscess, hyperventilation, R/O hyperthyroidism
3. Respiratory alkalosis (acute)
4. ? Septic: pyelonephritis, renal abscess
? Anxiety: biochem test
5. IV's to hydrate N/S
CT of abdomen and pelvis
Note: respiratory hyperventilation may also be due to infection (sepsis)
Other factors include hyperthyroidism and anxiety