Activity 8 - Structural Activity Relationship Of Beta-Lactam Antibiotics Flashcards Preview

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Flashcards in Activity 8 - Structural Activity Relationship Of Beta-Lactam Antibiotics Deck (18):
1

It refers to what the body does to a drug.

Pharmacokinetics

2

It refers to the movement of drug into, through and out of the body- the time course of its absorption, bioavailability, distribution, metabolism and excretion.

Pharmacokinetics

3

It refers to what the drug does to the body.

Pharmacodynamics

4

It involves the receptor binding, post receptor effects, and chemical interactions.

Pharmacodynamics

5

The study of action or effects of drugs on the body/living organism.

Pharmacodynamics

6

Capable of inhibiting the growth or reproduction of bacteria.

Bacteriostatic

7

Agents that kill bacteria.

Bactericidal

8

Destruction or decomposition, as of a cell or other substances under the influence of a specific agent.

Lysis

9

The time it takes for a substance to lose half of its pharmacological, physiologic or radiological activity.

Half-life

10

4th generation cephalosporins

1. Cefepime
2. Cefpirome
3. Cefoselis

11

For gram positive bacteria

1st generation cephalosporins

12

For gram negative bacteria

2nd generation cephalosporins

13

For gram negative and penicillinase-resistant bacteria

3rd generation cephalosporins

14

For both gram positive and negative bacteria

4th generation cephalosporins

15

Side effect of penicillins and cephalosporins

Hypersensitivity

16

Ticarcillin is paired with what beta-lactamase inhibitor?

Clavulanic acid

17

What process in bacteria does penicillins and cephalosporins interrupt?

Peptidoglycan synthesis

18

Medicines that cannot be taken with penicillins:

1. Allopurinol
2. Oral contraceptives
3. Methotrexate