Acute Inflammation Flashcards Preview

Cells > Acute Inflammation > Flashcards

Flashcards in Acute Inflammation Deck (16):
1

Function of inflammatory response

A protective response intended to eliminate the initial cause of cell injury and necrotic cells and tissue resulting from the original insult

2

Steps of Inflammatory Response

Recognition of injurious agent
Recruitment of leukocytes
Removal of agent
Regulation of the response
Resolution

3

Chracteristics of Acute Inflammation

Increase in erythema
Inc permeability
Edema
Accumulation of leukocytes

4

Hemodynamic changes

Initially vasocontriction
Arteriol vasodialation
Vascular expansion (erythema)

5

Vascular Changes

Inc permeability - PP can cross into tissue
Inc pressure
Blood stasis - blood slows down
- Leads to margination of neutrophils

6

Pressure changes

Inc in hydrostatic p.
Dec Colloid p.

- Initial inc in p. causes fluid into tissue (transudate)
- As permeability inc, PP flow into tissue
- PP cause more fluid to flow into tissue (exudate)

7

Permeability changes

Chemical mediators - contraction of EC
Cytokines
EC dmg - releases cytokines
Neutrophil and EC interaction - release cytokines
(Inc transcytosis)

8

Cytokines in platelets
- Platelet activating factor
- Seratonin

- PAF: Also in Neutrophils, triggers aggrigation of platelets (thromboxanes also trigger aggrigation), Vasocontriction

- Seratonin: Released when platelets aggregate, Vasodilation

9

Platelet growth factors

- EGF: proliferation of epithelial cells
- PDGF: Regulates chemotaxis of fibroblasts and monocytes
- FGF: synthesis of ECM pro
- TGF-b: inhibits growth of epithelial cells

10

Histamine

- Located in mast cells
- Dialate BV
- Increase vascular permeability

11

Vasodilators vs vasoconstrictors factors

Vasodilators:
- Histamine
- IL-1, TNF
- Seratonin
- Prostoglandins

Vasoconstictors:
- Leukotrines
- Thromboxanes
- PAF

12

Lipoxygenase (antiinflammatory)

- Leukotrines: vasoconstrictor
- Lipoxines: inhibit l,p,e-selectins, ICAMS, integrins from binding

13

cyclooxygenase

- Prostoglandins: vasodialator, mediate pain and fever
- Thromboxanes: aggregate platelets, vasoconstrictor

*Aspirin, NSAIDs, COX-2 inhibitors block this pathway

14

Pain and fever mediators

Pain: prostoglandins, bradykinin

Fever: TNF, IL-1, prostoglandins

15

Factor XII

PP that activates Kinin cascade and clotting cascade

16

Kinin cascade

Activates bradykinin (localized p!)
Activates complement cascade (antibodies and phagocytosis)