Acute Interstitial Nephritis

Question 1

What drugs commonly cause acute interstitial nephritis?

Answer 1

Abx most common:
penicillin
rifampicin

Others:
NSAIDs
allopurinol
furosemide

Question 2

What systemic diseases can cause acute interstitial nephritis?

Answer 2

SLE
sacroidosis
Sjogrens

Question 3

What infections can cause acute interstitial nephritis?

Answer 3

Hanta virus
staphylococci

Question 4

Describe AIN on histology

Answer 4

• marked interstitial oedema
• interstitial infiltrate in the connective tissue between renal tubules

Question 5

Clinical features of AIN

Answer 5

Fever
rash
arthralgia
eosinophilia
mild renal impairment
hypertension

Question 6

What investigations can be used to help diagnose AIN?

Answer 6

sterile pyuria
white cell casts

Question 7

Which condition(s) does the following describe:

Young female with fever, weight loss and painful, red eyes.

Urinalysis is positive for leukocytes and protein.

Answer 7

Tubulointerstitial nephritis with uveitis