Adalimumab Flashcards
1
Q
drug classification
A
monoclonal antibody
2
Q
target
A
tumour necrosis factor alpha/TNF alpha
3
Q
mechanism of action
A
binds with specificity to TNF alpha
inhibits interaction with p55 and p75 cell surface TNF receptors
4
Q
physiology
A
TNF mainly secreted by macrophages and can induce cell death of certain tumour cell lines
reduction in TNF reduces apoptosis
changes levels of adhesion molecules responsible for leukocyte migration in inflammation
5
Q
used to treat
A
inflammatory conditions
6
Q
cautions
A
difficult and expensive to produce
limited usage to those that don’t respond to other therapies
7
Q
side effects
A
anaemia
anxiety
coagulation disorder
dehydration
