Adaptive Immune Diseases Flashcards Preview

4.) H&D > Adaptive Immune Diseases > Flashcards

Flashcards in Adaptive Immune Diseases Deck (23):
1

What contibutes to Autoimmune DIsease?

Mess up in Negative selction w/ B and T Cells

2

What are the 4 types of ADs that are T-cell mediated? (Type IV)

1. Diabetes type 1
2. Rheumatold arthritis
3. Multiple sclerosis
4. Celiac Disease

3

What are the 3 Immune-complex disease (type III)?

Endocarditis
Cryoglobulinemia
Erythematosus (lupus)

4

What SEX gets more ADs?

Females

5

How many of those that have the predisposed gene actually get autoimmune disease?

20%

6

What 3 things cause ADs?

Genetics
Environment
Both (trauma can too)

7

What Gene is associated w/ ADs 50% of the time?

HLA

8

What cells are closly tied w/ AD development?

CD4 T-Cells
(Class II)

9

Rheumatic Fever is casued by...

Molecular Mimicry

10

Strep Pyogenes cause... why?

Rheumatic Fever and they share human epitopes

11

Graves' Disease is caused by what cell response?

CD4 Th2

12

In Graves' Disease Antibodies function as...

a TSH agonist

13

Can Graves' Disease be given to babies?

Yup they sure can dude

14

What cells respond to Hashimoto's Disease?

CD4 TH1

15

What is Hashimoto's Dsease?

Hypothyroidism

16

Hyperthyroidism is

Graves' Disease

17

Hypothyroidism is

Hashimoto's Disease

18

What type of Hypersensitivity is Sjorgen's Syndrome?

Type II

19

Some Symptoms of Sjogren's Syndrome

Dry everything
Things that happen w/ dry mouth

20

What comes w. Lupus?

Kidney Dysfunction and a face wolf mask thing

21

How is Periodontitis related to Rheumatoid Arthritis?

By epitope spreading w/ citrullinated proteins

22

Type IV Hypersensitivity is mediated by

CD4 and CD8

23

What is the Epitope Spreading w. Type I Diabetes?

Intraepitope
Interepitope