Adrenal gland Flashcards Preview

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Flashcards in Adrenal gland Deck (13):
1

what does cholesterol needs to be packaged as in adrenal gland

cholesteryl esters

2

which enzyme is common to have a defect for cortisol and aldosterone synthesis? what type of defect is it?

17 alpha hydroxylase; congenital hyperplasia

3

what does glucocorticoid suppress in inflammatory response?

inhibit release of arachidonic acid and repression of cyclooxygenase to inhibit prostaglandin synthase system to inhibit prostaglandin

4

Action of glucocorticoid

Protein catabolism
Inhibit glucose uptake by adipose tissue
gluconeogensis

goal is to conserve glucose.

5

Degradation of steroid hormone

1. diffuse and inactivate steroid by hydroxylating them (reduction)

2. conjugation w/ glucuronic acid: adding hydrophilic molecule to excrete in urine

6

Cushing disease hormone levels

high glucocorticoid, mineral corticoid, excess ACTH

7

addison disease homeone levels

low glucocorticoid, mineralcorticoid, EXCESS ACTH (loss of feedback)

8

cushing disease protein metabolism

thiinning of skin, loss of bone, pour wound healing, muscle wasting, impaired growth

9

carb metabolism and lipid metabolism on cushing disease

abnormal glucose tolerance; overt diabetes mellitus


moon phase/centripetal fat distrubtion---fat everyweher else besides adipose

10

carb metabolism on addison disease

hypoglycemia

11

other effects of cushing disease and addison

Cushin:loss of blood cells

impaired immune function

addison: pimentation of skin

12

electrolyte balance between cushing disease and addison

cushing: Na retention, K+ loss, hypertension

addison: Na loss, K+ retension, hypotension

13

Aldosterone effect

increase Na uptake, increase BP