Adrenal Steroids Flashcards Preview

Pharmacology > Adrenal Steroids > Flashcards

Flashcards in Adrenal Steroids Deck (12):
0

Inhaled corticosteroids

Fluticasone, beclomethasone, flunisolide, triamcinolone

1

Topical corticosteroids

Cortisol, methylprednisolone, dexamethasone

2

Depot corticosteroids

Methylprednisolone suspended in polyethylene glycol

3

Mifepristone

Glucocorticoid antagonist - progesterone receptor antagonist

Used in induce abortion in early pregnancy.
At high levels blocks glucocorticoid receptors- Tx of life threatening elevated glucocorticoids in ectopic ACTH syndrome

4

Mitotane

Synthesis inhibitors - mitochondria - all pathways

5

Aminoglutethimide.

Synthesis inhibitors - inhibits side chain cleavage enzyme cyp11a1

All pathways

6

Ketoconazale

Synthesis inhibitors - inhibits 17,20 lyase

Low levels decreases androgen synthase
Highly levels decreases all adrenal and gonadal steroid synthesis

7

Metyrapone

Synthesis inhibitors

11- B- hydroxylase
Decreases cortisol and aldosterone

8

Trilostane

Synthesis inhibitor - 3 B hydroxysteroid dehydrogenase

All but primarily cortisol and aldosterone

9

Fludrocortisone

Mineralocorticoid agonist

High mineral corticoid/ glucocorticoid activity ratio
Side effects same as having excessive aldosterone production ( extra cellular volume expansion, hypokalemia, HTN, k wasting, - renin release)

10

Spironolactone

Mineralcorticoid antagonist

K sparing diuretic
- androgen and progesterone receptor antagonist
Causes gynecomastia in males

11

Eplerenone

Mineral. Antagonist

K sparing diuretics
Pure Mineralcorticoid receptor antagonist