Hydrocortisone
regulates transcripts of target genes in nucleus to alter synthesis of inflammatory proteins
• Uses:
Severe allergic reactions
Relieve inflammatory bowel disease
• Effects:
Gluconeogenesis
Addison’s
too little cortisol (chronic)—often insufficient aldosterone as well
Treatment—corticol supplements: cortisones (hydro-) or prednisone
Cushing’s
high levels of cortisol—usually due to ACTH-secreting tumor
• Symptoms Buffalo hump (fatty deposits on upper back between shoulders Osteoporosis Hypertension Emotional
• Treatment-
Ketoconazole- inhibits adrenal steroid synthesis
Metyrapone-reduces cortisol synthesis
Mifepristone- steroid receptor antagonist
Denosumab
monoclonal ab for treatment of excess bone resorption
Teriparatide (Forteo)
selectively activates osteoblasts for treating osteoporosis
Vitamin D
stimulates absorption of Ca++ in intestines
Alendronate (Fosomax), Ibandronate (Boniva)
Bisphosphonates
inhibit osteoclasts
Flu like symptoms
Paget’s disease of bone
- Osteoclast and osteoblast regulation disrupted leading to malformed bones-large, dense and brittle
- Treatment: alendronate
Ketoconazole
inhibits adrenal steroid synthesis
treats Cushing’s
Metyrapone
reduces cortisol synthesis
treats cushing’s
Mifepristone
steroid receptor antagonist
treats cushing’s