Adrenals III Flashcards
what type of cells are in adrenal nmedulla
specialized neural crest cells “chromaffin cells”
supporting “sustentacular cells”
what does the adrenal medulla produce
catecholamines like epi and norepi
what are the adrenal medulla neoplasms
chromaffin cells- pheochromocytoma
-neuronal - neuroblastic tumors
surgically corrected HTN
pheochromocytoma
what are paragangliomas
extra-adrenal pheochromcytomas
found in carotid body
how many sporadic adrenal pheos are b/l
10%
malignancy is more common in what pheos
the extra adrenal paragangliomas
do all adrenal pheochromocytomas have HTN
10% do not
what germline utations are assoc with pheochromocytomas
RET in MEN2A/B
NF1 in neurofibromatosis
what can cause both pheo and paragangliomas
vHL
familial paraganglioma 1 SDHD
familial paraganglioma 4 SDHB
what is morphology of pheochromcytoma
richly vascularized fibrous trabeculae in tumor produce lobule pattern
incubation of fresh tissue with K dichromate solution will turn the tumor dark brown color from oxidaion of stored catecholamines “chromaffin”
zellballen nest of cells
pheochromocytomas
what are the paroxysmal episodes assoc with pheochromocytoma
tachy, palpitations, HA, sweating, tremor and sense of apprehension
pain assoc with pheochromocytoma paraoxysmal episodes
pain in abdomen, chest, nause, vomiting
paroxysms of pheos precipitated by
emotional stress, exercise, changes in posture and palpation in region of the tumor
