Adrenergics: Indirect Acting Adrenergic agonists Flashcards Preview

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Flashcards in Adrenergics: Indirect Acting Adrenergic agonists Deck (34)
1

release endogenous norepinephrine from nerve terminals

Indirect acting adrenergic antagonist

2

Indirect acting only :

only action is to release norepinephrine

3

What is my only indirect acting drug that's only action is to release Nepi?

Tyramine

4

Tyramine releases Nepi from ________ nerves and causes sympathomimetic actions

Sympathetic

5

Found at high levels in certain foods (fermented foods such as wines, beer, certain cheeses and sausages)

Tyramine

6

What enZ will metabolizes tyramine to inactive prodcuts?

monoamine oxidase

7

Why type of drug do we need to be careful of if a patient is eating foods like wine, beer, cheese and sausages

In patients taking monoamine oxidase inhibitors, ingestion of food with high
levels of tyramine(beer, sausage, wine) can cause hypertensive crisis

8

Type of indirect acting adrenergic drug class that will increase Nepi release and stimulate adrenergic receptors

Mixed acting

9

Two examples of mixed acting indirect acting adrenergics

Ephedrine and Amphetamine

10

Amphetamine is a powerful sytimulant of :

CNS

11

Amphetamine is a powerful CNS stimulant in addition to:

peripheral α and β receptor actions

12

Amphetamine is effective after oral administration – ______ t 1⁄2

long

13

This drug releases NE from adrenergic neurons but also a weak direct α and β agonist

Amphetamine

14

Besides releasing NE from adrenergic neurons, what weaker effect does amphetamine have?

weak direct alpha and beta agonist

15

What affect does amphetamine have on the NE transporter (NET)?

weakly blocks the norepinephrine transporter (NET)

16

What effect does amphetamine have on appetite?

- Depresses appetite

17

This drug therapy is used to treat narcolepsy, attention deficit disorder

Amphetamines

18

Ephedrine has____ asymmetric carbons creating ____isomers

two
4

19

4 isomers of ephedrine:

: d- and l- ephedrine and d- and l- pseudoephedrine

20

Ephedrine is effective:

Orally

21

Ephedrine works how and on which receptors?

direct agonist (α and β receptors) and releases NE that activates adrenergic receptors

22

What does ephedrine do to CNS?

CNS stimulation

23

some herbal preparations contain ephedrine (ma huang, ephedra), resultin in

inadvertent consumption of high doses of ephedrine

24

previously used to treat asthma, but has been replaced by β2 agonists -

Ephedrine

25

Pseudoephedrine
- direct _______activity with little ______activity

α1 agonist
β2 agonist

26

Major therapeutic use: nasal decongestant (due to α1 agonist effects)

pseudophedrine

27

used as a precursor to illegally synthesize methamphetamine

psedophedrine;
legislation in 2006 requires pharmacies to collect personal information from buyers and to limit its sale to a 30-day supply

28

Why is pseudophedrine a good drug therapy for nasal decongestant?

because of it's alpha 1 agonist effects

29

Side effects and toxicity of adrenergic agonists
1. Throbbing headache due to potent vasoconstriction – (receptor and action responsible

α agonists

30

Side effects and toxicity of adrenergic agonists
Increased heart rate (palpitations) (receptor and action responsible)

β agonists

31

Side effect and toxicity of adrenergic agonist:
Pericardial pain (angina) usually due to increased heart rate (receptor and action responsible)

β agonists

32

Side effect and toxicity of adrentergic agonist: Cardiac arrhythmias -(receptor and action responsible)

β agonists

33

Side effect and toxicity of adrenergic agonist: Cerebral hemorrhage – due to ↑ systemic blood pressure -(receptor and action responsible)

α agonists

34

Side effect and toxicity of adrenergic agonist:
Restlessness, anxiety, etc. (receptor and action responsible)

α and β agonists