Adrenergics, SNS Agents

Question 1

Out of NE, Epi, and Isoproterenol, which gives lowest peripheral resistance?

Answer 1

Isoproterenol

Unopposed Beta 2

Question 2

Propanolol, Nadolol, Pindolol, and timolol are all _____ Beta Blockers

Answer 2

Nonselective

Question 3

Epinephrine MOA, which receptors? What happens to pulse pressure?

Answer 3

B1=B2,
a1=a2
Widens pulse pressure

Question 4

Main side effect of Non-selective Alpha Antagonists?

Answer 4

Postural Hypotension

Question 5

Prototypical Alpha 1 agonist

Answer 5

Phenylephrine

Question 6

3 Main Non-Selective Beta Blockers

Answer 6

1. Propanolol
2. Nadolol
3. Pindolol

Question 7

Isoproteronol MOA? What happens to pulse pressure?

Answer 7

• B1=B2

- Pulse pressure Drops

Question 8

Prototypical Adrenergic Beta 1 agonist

Answer 8

Dobutamine

Question 9

Name 4 Main B1 Selective Blockers

Answer 9

1. Metoprolol
2. Acebutolol (ISA)
3. Nebivolol
4. Esmolol

Question 10

Dopamine at low doses vs High doses effects

Answer 10

Low: Increase renal perfusion & diuresis
High: B1 and Alpha Effect

Question 11

Alpha-methyl dopa main side effect

Answer 11

Dug-Induced lupus

Question 12

Two main Adrenergic Alpha 2 Agonists

Answer 12

• Clonidine

- Alpha-Methyl Dopa

Question 13

Two contraindications of Epi

Answer 13

1. Hyperthyroidism

2. On non-selective Beta Blocker

Question 14

3 Side effects of Dopamine

Answer 14

1. Vent/SVT arrhythmias
2. Wide QRS
3. Angina

Question 15

Adminster ______ to reverse Beta Blocker Toxcity

Answer 15

Glucagon

Question 16

Phenoxybenzamine MOA

Answer 16

Irreversible a1=a2 Block

- Blocks vasoconstrict

Question 17

Norepinephrine MOA, which receptors? What happens to pulse pressure?

Answer 17

B1»>B2 (no Beta2)
a1=a2
Pulse pressure mild boost (both SBP and DBP go up)

Question 18

Out of the 4 Alpha-1 Blockers, ) ______ has the longest half life and _______ is the most Uro-selective

Answer 18

• Doxazosin

- Taumulosin

Question 19

Two Non-selective Alpha Antagonists

Answer 19

1. Phenoxybenzamine (IRR)

2. Phentolamine (Rev)

Question 20

Metoprolol, Acebutolol (ISA), Nebivolol, Betaxolol, and Esmolol are all _____ Beta Blockers

Answer 20

B1

Question 21

Out of the B1 selective blockers, name why each is special.

• Esmolol
• Nebivolol
• Acebutolol

Answer 21

• Esmo is the shortest acting
• Nebi is the longest acting
• Ace has partial agonist

Question 22

Prazosin, Terazosin, Doxazosin, and Tamulosin are all ___ ____ ____

Answer 22

Selective Alpha 1 Blockers

Question 23

Alpha-methyl Dopa Main use

Answer 23

HTN in pregnancy

Question 24

Dobutamine MOA

Answer 24

• B1 Agonist

- some alpha1 maintains resistance

Question 25

Phentolamine MOA

Answer 25

Reversible a1=a1 Block | - Blocks vasoconsrict

Question 26

Aside from cardiac arrest and heart block, what is Isoproteronol used for?

Answer 26

Stokes-Adams Attack | Syncope from brady

Question 27

Labetolol and Carvedilol are both _____ Beta blockers

Answer 27

``` Mixed Nonselective (Also block Alpha) ```

Question 28

Phentolamine and Phenoxybenzamine are both used to treat _______

Answer 28

Pheochromocytomas

Question 29

Pindolol is the weirdest Non-Selective Beta Blocker because:

Answer 29

It's also Partial agonist to B1 and B2

Question 30

Clonidine 2 main uses

Answer 30

1. Hypertensive Urgency | 2. Anxiolytic

Question 31

2 uses for Dobutamine

Answer 31

1. Cardiogenic Shock | 2. Cardiac Stress test

Question 32

Never use Beta blockers for _______ Angina

Answer 32

Vasospastic | You want B2 to function

Question 33

Main side-effect of Phenylephrine

Answer 33

Supine HTN

Question 34

4 Selective Alpha 1 Blockers

Answer 34

1. Prazosin 2. Terazosin 3. Doxazosin 4. Tamulosin

Question 35

Prototypical Non-selective Beta Agonist?

Answer 35

Isoproteronol

Question 36

Alpha-Methyl Dopa MOA

Answer 36

Alpha 2 Agonist | - Decrease SNS outflow

Question 37

NE Major side effect?

Answer 37

Ischemic Necrosis

Question 38

Clonidine MOA

Answer 38

Alpha 2 agonist | - decrease tone, HR, SNS outflow

Question 39

Epi is used for _____ whereas NorEpi is used for _____ in ______ or _____ _____

Answer 39

- Anaphylaxis - Hypotension, Sepsis - Cardiogenic Shock

Question 40

Phenylephrine MOA

Answer 40

Alpha 1 agonist constriction