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Flashcards in Adrenocorticosteroids Deck (2)
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1

Corticosteroids

➢ Hormones secreted by outer cortex of adrenal gland.
➢ Classified as those having:
1. Effect on intermediary metabolism & immune function:
• Glucocorticoids → Cortisol
2. Salt retaining property –
• Mineralocorticoids....Aldosterone
3. Androgenic or estrogenic activity –
• Sex steroids …..Testosterone, Estrone

2

Synthesis of corticosteroids

➢ Both mineralocorticoids and glucocorticoids are synthesized from cholesterol
• Synthesized and stored in minute quantities
➢ Normal rate of secretion of two principle corticoids:
• Hydrocortisone: 10 mg daily (more than ½ in the morning)
• Aldosterone: 0.125 mg daily