Adrenoreceptors Flashcards Preview

Pharmacology > Adrenoreceptors > Flashcards

Flashcards in Adrenoreceptors Deck (19)
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1
Q

Where are alpha 1 receptors located

A

Vascular smooth muscle
Pupil dilator muscle
GIT

2
Q

Where are alpha 2 receptors located

A

Nerve terminals
Vascular smooth muscle
Platelets

3
Q

Where are beta 1 receptors located

A

Heart
Kidneys
GIT

4
Q

Where are beta 2 receptors located

A

Lungs
Liver
Vascular Smooth muscle

5
Q

Where are beta 3 receptors located

A

Adipocytes

6
Q

Activation of alpha 1 receptors causes

A

Vasoconstriction

GIT relaxation

7
Q

Activation of alpha 2 receptors causes

A

Pre-synaptic inhibition
Vasoconstriction
Platelet aggregation

8
Q

Activation of beta 1 receptors causes

A

Increase contractility/ionotropy
Increase renin secretion
Relaxation

9
Q

Activation of beta 2 receptors causes

A

Smooth muscle relaxation- bronchodilation
Vasodilation
Activate Glycogenolysis

10
Q

Activation of beta 3 receptors causes

A

Activate lipolysis

11
Q

Alpha 1 agonist

A

Phenylephrine

12
Q

Alpha 1 antagonist

A

Phentolamine

Labetalol

13
Q

Alpha 2 agonist

A

Clonidine

14
Q

Alpha 2 antagonist

A

Phentolamine

Prazosin

15
Q

Beta 1 agonist

A

Isoprenaline

Dobutamine

16
Q

Beta 1 antagonist

A

Atenalol
Propranolol
Labetalol

17
Q

Beta 2 agonist

A

Isoprenaline

Salbutamol

18
Q

Beta 2 antagonist

A

Propranolol

19
Q

Mechanism of each adrenorecptor

A
a1- Gq   (PLC- increase Ca)
a2-Gi    (decrease cAMP- decrease NA)
B1-Gs   (increase cAMP)
B2-Gs
B3- Gs