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Flashcards in Aerobic Metabolism Deck (13)
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1
Q

Where does TCA cycle occur?

A

Mito matrix

2
Q

What enz cat link reaction?

A

Py dehy

3
Q

What does FAD stand for?

A

Flavin adenine dinucleotide

4
Q

How much ATP, ADP + Pi is gen from NADH?

A

2.5

5
Q

Which 3 enz in TCA cycle irrev and why?

A

citrate synthetase
isocitrate dehydrogenase
ketoglutarate dehydrogenase – to drive cycle in 1 direction

6
Q

Write the equation for the activation of acetate by CoA

A

Acetate + CoA –> A CoA + H2O

7
Q

What is the equation for the link reaction?

A

Py + NAD+ + CoA –> A CoA + CO2 + NADH + H+

8
Q

What drives the cycle?

A

Build up of oxaloacetate

9
Q

How is rate of TCA cycle reg?

A

by feedback inhibition of key enzymes

10
Q

How can glucose be made directly from TCA cycle?

A

Oxal –> phosphoenol py –> glucose by PEP carboxylase

11
Q

What is the structure of CoA?

A

ADP, Pantoic acid, β-alanine, cysteamine

12
Q

Which other cofactors are required for LR?

A

thiamine pyrophosphate, lipoic acid, FAD, Coenzyme A

13
Q

Why is CO2 prod in LR?

A

Going from py (3c) to A CoA (2C)