Aerosol Drug Therapy Flashcards Preview

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Flashcards in Aerosol Drug Therapy Deck (35):
1

the mass of fluid or drug contained in aerosol produced by a nebulizer

Aerosol output

2

the mass of drug leaving the mouthpiece of a nebulizer or inhaler as aerosol.

emitted dose

3

Aerosols consisting of particles of similar size (GSD ≤ 1.2)

monodisperse

4

Most aerosols found in nature and used in respiratory care are composed of particles of different sizes, described as

heterodisperse

5

Key mechanisms of aerosol deposition include

inertial impaction, gravimetric sedimentation, and brownian diffusion

6

suspended particles in motion collide with and are deposited on a surface; this is the primary deposition mechanism for particles larger than 5 µm

Inertial impaction

7

aerosol particles settle out of suspension and are deposited owing to gravity.

Sedimentation

8

During normal breathing, what is the primary mechanism for deposition of particles 1 to 5 µm.

sedimentation

9

T/F The greater the mass of the particle, the faster it settles

True

10

Do what after inhalation of an aerosol increases the residence time for the particles in the lung and enhances distribution across the lungs and sedimentation

Breath holding

11

T/F A 10-second breath hold can increase aerosol deposition 10% and increase the ratio of aerosol deposited in lung parenchyma to central airway by fourfold.

True

12

the primary mechanism for deposition of small particles

Brownian diffusion

13

process by which an aerosol suspension changes over time

aging

14

Aerosol particles can change size as a result of either

evaporation or hygroscopic water absorption.

15

the amount of drug inhaled.

Inhaled mass

16

The proportion of the drug mass in particles that are small enough(fine-particle fraction) to reach the lower respiratory tract

respirable mass

17

Mdi- Manufacturers recommend how long between actuations.

30 seconds to 1 minute

18

(MDI) shaking the device and releasing one or more sprays into the air

Priming

19

(DPI) . Patients must generate an inspiratory flow rate of at least ______ L/min to produce a respirable powder aerosol

40 to 60

20

medication that remains in the SVN after the device stops generating aerosol and “runs dry

Residual drug volume, or dead volume,

21

Higher flow does what to aerosol particles ?

makes them smaller

22

(SVN) generate aerosol continuously, using a system of vents and one-way valves to minimize aerosol waste.

Breath-enhanced nebulizers

23

(SVN) generate aerosol only during inspiration

Breath-actuated nebulizers

24

What kind of SVN is Pari LC Sprint

Breath-enhanced nebulizer

25

What kind of SVN is aero eclipse

Breath-actuated nebulizer

26

The CDC recommends that nebulizers be cleaned and disinfected, or rinsed with sterile water, and air dried how often?

between uses

27

What is particularly useful when traditional dosing strategies are ineffective in the management of severe bronchospasm

large volume nebulizer

28

T/F Another special-purpose large volume nebulizer is a small particle aerosol generator (SPAG) ribavirin (Virazole) to infants with respiratory syncytial virus infection.

True

29

used to administer sympathomimetic, anticholinergic, antiinflammatory, and anesthetic aerosols to the upper airway, including nasal passages, pharynx, and larynx. NO baffle High Particle size

Hand-bulb atomizers and nasal spray pumps

30

a piezoelectric crystal to generate an aerosol. The crystal transducer converts an electrical signal into high-frequency (1.2- to 2.4-MHz) acoustic vibrations. These vibrations are focused in the liquid above the transducer, where they disrupt the surface and create oscillation waves

USN

31

(USN) Output is determined by the amplitude setting (sometimes user-selected); the greater the signal amplitude, the greater the nebulizer output. Particle size is inversely proportional to

the frequency of vibrations.

32

what kind of neb is a DeVilbiss Portasonic nebulizer

USN

33

Large volume USNs are used mainly for

bland aerosol therapy or sputum induction

34

Low flow through the USN is associated with

smaller particles and higher mist density

35

(USN) High flow yields

larger particles and less density.