Flashcards in Aerosol Drug Therapy Deck (35):
the mass of fluid or drug contained in aerosol produced by a nebulizer
the mass of drug leaving the mouthpiece of a nebulizer or inhaler as aerosol.
Aerosols consisting of particles of similar size (GSD ≤ 1.2)
Most aerosols found in nature and used in respiratory care are composed of particles of different sizes, described as
Key mechanisms of aerosol deposition include
inertial impaction, gravimetric sedimentation, and brownian diffusion
suspended particles in motion collide with and are deposited on a surface; this is the primary deposition mechanism for particles larger than 5 µm
aerosol particles settle out of suspension and are deposited owing to gravity.
During normal breathing, what is the primary mechanism for deposition of particles 1 to 5 µm.
T/F The greater the mass of the particle, the faster it settles
Do what after inhalation of an aerosol increases the residence time for the particles in the lung and enhances distribution across the lungs and sedimentation
T/F A 10-second breath hold can increase aerosol deposition 10% and increase the ratio of aerosol deposited in lung parenchyma to central airway by fourfold.
the primary mechanism for deposition of small particles
process by which an aerosol suspension changes over time
Aerosol particles can change size as a result of either
evaporation or hygroscopic water absorption.
the amount of drug inhaled.
The proportion of the drug mass in particles that are small enough(fine-particle fraction) to reach the lower respiratory tract
Mdi- Manufacturers recommend how long between actuations.
30 seconds to 1 minute
(MDI) shaking the device and releasing one or more sprays into the air
(DPI) . Patients must generate an inspiratory flow rate of at least ______ L/min to produce a respirable powder aerosol
40 to 60
medication that remains in the SVN after the device stops generating aerosol and “runs dry
Residual drug volume, or dead volume,
Higher flow does what to aerosol particles ?
makes them smaller
(SVN) generate aerosol continuously, using a system of vents and one-way valves to minimize aerosol waste.
(SVN) generate aerosol only during inspiration
What kind of SVN is Pari LC Sprint
What kind of SVN is aero eclipse
The CDC recommends that nebulizers be cleaned and disinfected, or rinsed with sterile water, and air dried how often?
What is particularly useful when traditional dosing strategies are ineffective in the management of severe bronchospasm
large volume nebulizer
T/F Another special-purpose large volume nebulizer is a small particle aerosol generator (SPAG) ribavirin (Virazole) to infants with respiratory syncytial virus infection.
used to administer sympathomimetic, anticholinergic, antiinflammatory, and anesthetic aerosols to the upper airway, including nasal passages, pharynx, and larynx. NO baffle High Particle size
Hand-bulb atomizers and nasal spray pumps
a piezoelectric crystal to generate an aerosol. The crystal transducer converts an electrical signal into high-frequency (1.2- to 2.4-MHz) acoustic vibrations. These vibrations are focused in the liquid above the transducer, where they disrupt the surface and create oscillation waves
(USN) Output is determined by the amplitude setting (sometimes user-selected); the greater the signal amplitude, the greater the nebulizer output. Particle size is inversely proportional to
the frequency of vibrations.
what kind of neb is a DeVilbiss Portasonic nebulizer
Large volume USNs are used mainly for
bland aerosol therapy or sputum induction
Low flow through the USN is associated with
smaller particles and higher mist density