Agent Used In Anemias & Hematopoietic Growth Factors Flashcards Preview

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Flashcards in Agent Used In Anemias & Hematopoietic Growth Factors Deck (57):
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Iron

Ferrous sulfate
Ferrous gluconate
Ferrous fumarate
Iron dextran
Iron sucrose complex
Sodium ferric gluconate complex

1

Oral iron preperations

Ferrous gluconate
Ferrous fumarate

2

Ferrous gluconate
Ferrous fumarate

Oral iron preperations

3

Iron dextran
Iron sucrose complex
Sodium ferric gluconate complex

Parenteral preparation; can cause pain, hypersensitivity reactions

4

Parenteral preparation; can cause pain, hypersensitivity reactions

Iron dextran
Iron sucrose complex
Sodium ferric gluconate complex

5

Ferrous sulfate

Mechanism of action

Required for biosynthesis of heme and heme-containing proteins, including hemoglobin and myoglobin

6

Ferrous sulfate

Mechanism of action

Required for biosynthesis of heme and heme-containing proteins, including hemoglobin and myoglobin

7

Ferrous sulfate

Effects

Adequate supplies required for normal heme synthesis
Deficiency results in inadequate heme production

8

Adequate supplies required for normal heme synthesis
Deficiency results in inadequate heme production

Ferrous sulfate

Effects

9

Ferrous sulfate

Clinical applications

Iron deficiency, which manifests as microcytic anemia
Oral preparation

10

Ferrous sulfate

Effects

Ferrous sulfate

Clinical applications

11

Ferrous sulfate

Toxicity

Acute overdose results in necrotizing gastroenteritis, abdominal pain, bloody diarrhea, shock, lethargy, and dyspnea
Chronic iron overload results in hemochromatosis, with damage to the heart, liver, pancreas, and other organs
Orgen failure and death can ensue

12

Acute overdose results in necrotizing gastroenteritis, abdominal pain, bloody diarrhea, shock, lethargy, and dyspnea
Chronic iron overload results in hemochromatosis, with damage to the heart, liver, pancreas, and other organs
Orgen failure and death can ensue

Ferrous sulfate

Toxicity

13

Iron chelators

Deferoxamine
Deferasirox

14

Deferoxamine

Iron chelator

15

Deferasirox

Iron chelator

16

Deferasirox

Usage

Orally administered iron chelator for treatment of hemochromatosis

17

Orally administered iron chelator for treatment of hemochromatosis

Deferasirox

Usage

18

Deferoxamine

Mechanism of action

Chelates excess iron

19

Chelates excess iron

Deferoxamine

Mechanism of action

20

Deferoxamine

Effects

Reduces toxicity associated with acute or chronic iron overload

21

Reduces toxicity associated with acute or chronic iron overload

Deferoxamine

Effects

22

Deferoxamine

Clinical applications

Acute iron poisoning inherited or acquired hemochromatosis

23

Acute iron poisoning inherited or acquired hemochromatosis

Deferoxamine

Clinical applications

24

Deferoxamine

Toxicity

Rapid IV administration may cause hypotension
Neurotoxicity and incresed susceptibility to certain infection have occurred with long-term use

25

Rapid IV administration may cause hypotension
Neurotoxicity and incresed susceptibility to certain infection have occurred with long-term use

Deferoxamine

Toxicity

26

Vitamin B12

Cyanocobalamin
Hydroxocobalamin

27

Hydroxocobalamin

Vitamin B12

28

Cyanocobalamin

Vitamin B12

29

Cyanocobalamin (vitamin B12)
Hydroxocobalamin (vitamin B12)

Mechanism of action

Cofactor required for essential enzymatic reaction that form tetrahydrofolate, coverts homocysteine to methionine, and metabolize L-methylmalonyl-CoA

30

Cofactor required for essential enzymatic reaction that form tetrahydrofolate, coverts homocysteine to methionine, and metabolize L-methylmalonyl-CoA

Cyanocobalamin (vitamin B12)
Hydroxocobalamin (vitamin B12)

Mechanism of action

31

Cyanocobalamin (vitamin B12)
Hydroxocobalamin (vitamin B12)

Effects

Adequate supplies required for amino acid and fatty acid metabolism, and DNA synthesis

32

Adequate supplies required for amino acid and fatty acid metabolism, and DNA synthesis

Cyanocobalamin (vitamin B12)
Hydroxocobalamin (vitamin B12)

Effects

33

Cyanocobalamin (vitamin B12)
Hydroxocobalamin (vitamin B12)

Clinical applications

Vitamin B12 deficiency, which manifests as megaloblastic anemia and is the basis for pernicious anemia

34

Vitamin B12 deficiency, which manifests as megaloblastic anemia and is the basis for pernicious anemia

Cyanocobalamin (vitamin B12)
Hydroxocobalamin (vitamin B12)

Clinical applications

35

Cyanocobalamin (vitamin B12)
Hydroxocobalamin (vitamin B12)

Toxicity

No toxicity associated with excess

36

No toxicity associated with excess

Cyanocobalamin (vitamin B12)
Hydroxocobalamin (vitamin B12)

Toxicity

37

Reference range of vitamin B12

180-914 ng/L
or
150-900 pg/mL

38

180-914 ng/L
or
150-900 pg/mL

Reference range of vitamin B12

39

Folic acid

Folacin (pteroylglutamic acid)

40

Folacin (pteroylglutamic acid)

Folic acid

41

Folacin (pteroylglutamic acid)

Mechanism of action

Precursor of an essential donor for methyl groups used for synthesis of amino acids, purines, and deoxynucleotide

42

Precursor of an essential donor for methyl groups used for synthesis of amino acids, purines, and deoxynucleotide

Folacin (pteroylglutamic acid)

Mechanism of action

43

Folacin (pteroylglutamic acid)

Effects

Adequate supplies required for essential biochemical reactions involving amino acid metabolism, and purine and DNA synthesis

44

Adequate supplies required for essential biochemical reactions involving amino acid metabolism, and purine and DNA synthesis

Folacin (pteroylglutamic acid)

Effects

45

Erythrocyte-stimulating agents

Epoetin alfa
Darbepoetin alfa
Methoxy polyethylene glycol-epoetin beta

46

Darbepoetin alfa

Erythrocyte-stimulating agent

47

Methoxy polyethylene glycol-epoetin beta

Erythrocyte-stimulating agent

48

Epoetin alfa

Erythrocyte-stimulating agent

49

Epoetin alfa

Mechanism of action

Agonist of erythropoietin receptors expressed by red cell progenitors

50

Agonist of erythropoietin receptors expressed by red cell progenitors

Epoetin alfa

Mechanism of action

51

Epoetin alfa

Effects

Stimulates erythroid proliferation and differentiation, and induces the release of reticulocytes from bone marrow

52

Stimulates erythroid proliferation and differentiation, and induces the release of reticulocytes from bone marrow

Epoetin alfa

Effects

53

Epoetin alfa

Clinical applications

Anemia, especially anemia associated with chronic renal failure, HIV infection, cancer and prematurity
Prevention of the need for transfusion in patients undergoing certain types of elective surgery

54

Anemia, especially anemia associated with chronic renal failure, HIV infection, cancer and prematurity
Prevention of the need for transfusion in patients undergoing certain types of elective surgery

Epoetin alfa

Clinical applications

55

Epoetin alfa

Toxicity

Hypertension, thrombotic complications, and very rarely, pure red cell aplasia

56

Hypertension, thrombotic complications, and very rarely, pure red cell aplasia

Epoetin alfa

Toxicity