AGENTS, CONTROLLING THE FUNCTIONS OF THE CENTRAL NERVOUS SYSTEM - Antiseizure drugs Flashcards Preview

Pharmacology > AGENTS, CONTROLLING THE FUNCTIONS OF THE CENTRAL NERVOUS SYSTEM - Antiseizure drugs > Flashcards

Flashcards in AGENTS, CONTROLLING THE FUNCTIONS OF THE CENTRAL NERVOUS SYSTEM - Antiseizure drugs Deck (42):
1

The mechanism of action of antiseizure drugs is

- Enhancement of GABAergic (inhibitory) transmission
- Diminution of excitatory (usually glutamatergic) transmission
- Modification of ionic conductance

2

Which antiseizure drugs produces enhancement of GABA-mediated inhibition?

Phenobarbital

3

Indicate an antiseizure drug, which has an impotent effect on the T-type calcium channels in thalamic neurons?

Ethosuximide

4

Which antiseizure drugs produces a voltage-dependent inactivation of sodium channels?

- Lamotrigine
- Carbamazepin
- Phenytoin

5

Indicate an antiseizure drug, inhibiting central effects of excitatory amino acids

Lamotrigine

6

The drug for partial and generalized tonic-clonic seizures is

- Carbamazepine
- Valproate
- Phenytoin

7

Indicate an anti-absence drug

Valproate

8

The drug against myoclonic seizures is

Clonazepam

9

The most effective drug for stopping generalized tonic-clonic status epilepticus in adults is

Diazepam

10

Phenytoin

It blocks sodium channels

11

Phenytoin is used in the treatment of

Grand mal epilepsy

12

Dose-related adverse effect caused by phenytoin is

Gingival hyperplasia

13

Granulocytopenia, gastrointestinal irritation, gingival hyperplasia, and facial hirsutism are possible adverse effects of

Phenytoin

14

The antiseizure drug, which induces hepatic microsomal enzymes, is

Phenytoin

15

The drug of choice for partial seizures is

Carbamazepin

16

The mechanism of action of carbamazepine appears to be similar to that of

Phenytoin

17

Which antiseizure drugs is also effective in treating trigeminal neuralgia?

Carbamazepine

18

The most common dose-related adverse effects of carbamazepine are

Diplopia, ataxia, and nausea

19

Indicate the drug of choice for status epilepticus in infants and children

Phenobarbital sodium

20

Barbiturates are used in the emergency treatment of status epilepticus in infants and children because of

They significantly decrease of oxygen utilization by the brain, protecting cerebral edema and ischemia

21

Which antiseizure drugs binds to an allosteric regulatory site on the GABA-BZ receptor, increases the duration of the Cl-channels openings

Phenobarbital

22

Adverse effect caused by phenobarbital is

- Physical and phychological dependence
- Exacerbated petit mal epilepsy
- Sedation

23

Which antiseizure drugs is a prodrug, metabolized to phenobarbital?

Primidone

24

Indicate the antiseizure drug, which is a phenyltriazine derivative

Lamotrigine

25

Lamotrigine can be used in the treatment of

- Partial seizures
- Absence
- Myoclonic seizures

26

The mechanism of vigabatrin′s action is

Inhibition of GABA aminotransferase

27

Indicate an irreversible inhibitor of GABA aminotransferase (GABA-T)

Vigabatrin

28

Tiagabine

Blocks neuronal and glial reuptake of GABA from synapses

29

The mechanism of both topiramate and felbamate action is

- Reduction of excitatory glutamatergic neurotransmission
- Inhibition of voltage sensitive Na+ channels
- Potentiation of GABAergic neuronal transmission

30

The drug of choice in the treatment of petit mal (absence seizures) is

Ethosuximide

31

The dose-related adverse effect of ethosuximide is

- Gastrointestinal reactions, such as anorexia, pain, nausea and vomiting
- Exacerbated grand mal epilepsy
- Transient lethargy or fatigue

32

Valproate is very effective against

- Absence seizures
- Myoclonic seizures
- Generalized tonic-clonic seizures

33

The drug of choice in the treatment of myoclonic seizures is

Valproate

34

The reason for preferring ethosuximide to valproate for uncomplicated absence seizures is

Valproate′s idiosyncratic hepatotoxicity

35

The mechanism of valproate action is

- Facilitation glutamic acid decarboxylase, the enzyme responsible for GABA synthesis and inhibition of GABAaminotransferase, the enzyme responsible for the breakdown of GABA (enhance GABA accumulation)
- Inhibition of voltage sensitive Na+ channels
- Inhibition of low threshold (T-type) Ca2+ channels

36

Indicate the antiseizure drug, which is a sulfonamide derivative, blocking Na+ channels and having additional ability to inhibit T-type Ca2+ channels

Zonisamide

37

Indicate the antiseizure drug – a benzodiazepine receptor agonist

Lorazepam

38

Which antiseizure drugs acts directly on the GABA receptor-chloride channel complex?

Diazepam

39

Benzodiazepine΄s uselfulness is limited by

Tolerance

40

A long-acting drug against both absence and myoclonic seizures is

Clonazepam

41

Which antiseizure drugs may produce teratogenicity?

- Phenytoin
- Valproate
- Topiramate

42

The most dangerous effect of antiseizure drugs after large overdoses is

Respiratory depression

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