AGENTS, CONTROLLING THE FUNCTIONS OF THE CENTRAL NERVOUS SYSTEM - Narcotic analgesics Flashcards Preview

Pharmacology > AGENTS, CONTROLLING THE FUNCTIONS OF THE CENTRAL NERVOUS SYSTEM - Narcotic analgesics > Flashcards

Flashcards in AGENTS, CONTROLLING THE FUNCTIONS OF THE CENTRAL NERVOUS SYSTEM - Narcotic analgesics Deck (42):
1

Narcotics analgesics should

Relieve severe pain

2

Second-order pain is

Dull, burning pain

3

Chemical mediators in the nociceptive pathway are

- Kinins
- Prostaglandins
- Substance P

4

Chemical mediators in the nociceptive pathway are not

Enkephalins

5

Indicate the chemical mediator in the antinociceptive descending pathways

- BETA-endorphin
- Met- and leu-enkephalin
- Dynorphin

6

Which mediators is found mainly in long descending pathways from the midbrain to the dorsal horn?

Enkephalin

7

Select the brain and spinal cord regions, which are involved in the transmission of pain?

- The limbic system, including the amygdaloidal nucleus and the hypothalamus
- The ventral and medial parts of the thalamus
- The substantia gelatinosa

8

Mu (μ) receptors are associated with

Analgesia, euphoria, respiratory depression, physical dependence

9

Which opioid receptor types is responsible for euphoria and respiratory depression?

Mu (μ) receptors

10

Indicate the opioid receptor type, which is responsible for dysphoria and vasomotor stimulation

Kappa-receptors

11

Kappa and delta agonists

Close a voltage-gated Ca2+ channels on presynaptic nerve terminals

12

Which supraspinal structures is implicated in pain-modulating descending pathways?

The midbrain periaqueductal gray

13

Indicate the neurons, which are located in the locus ceruleus or the lateral tegmental area of the reticular formation

Nonadrenergic

14

Which analgesics is a phenanthrene derivative?

Morphine

15

Tick narcotic analgesic, which is a phenylpiperidine derivative

Fentanyl

16

Which opioid analgesics is a strong mu receptor agonist?

Morphine

17

Indicate the narcotic analgesic, which is a natural agonist

Morphine

18

Select the narcotic analgesic, which is an antagonist or partial mu receptor agonist

Pentazocine

19

Which agents is a full antagonist of opioid receptors?

Naloxone

20

The principal central nervous system effect of the opioid analgesics with affinity for a mu receptor is

- Analgesia
- Respiratory depression
- Euphoria

21

Which opioid analgesics can produce dysphoria, anxiety and hallucinations?

Pentazocine

22

Indicate the opioid analgesic, which has 80 times analgesic potency and respiratory depressant properties of morphine, and is more effective than morphine in maintaining hemodynamic stability?

Fentanyl

23

Which opioid analgesics is used in combination with droperidol in neuroleptanalgesia?

Fentanyl

24

Fentanyl can produce significant respiratory depression by

- Suppression of the cough reflex leading to airway obstruction
- Development of truncal rigidity

25

Most strong mu receptor agonists cause

Cerebral vasodilatation, causing an increase in intracranial pressure

26

Which opioid analgesics can produce an increase in the pulmonary arterial pressure and myocardial work?

Pentazocine

27

Morphine causes

- Constipation
- Urinary retention
- Bronchiolar constriction

28

Morphine do not causes

Dilatation of the biliary duct

29

Therapeutic doses of the opioid analgesics

Decrease body temperature

30

Which opioid analgesics is used in obstetric labor?

Meperidine

31

Indicate the opioid analgesic, which is used for relieving the acute, severe pain of renal colic

Meperidine

32

Which opioid analgesics is used in the treatment of acute pulmonary edema?

Morphine

33

The relief produced by intravenous morphine in dyspnea from pulmonary edema is associated with reduced

- Perception of shortness of breath
- Patient anxiety
- Cardiac preload (reduced venous tone) and afterload (decreased peripheral resistance)

34

Rhinorrhea, lacrimation, chills, gooseflesh, hyperventilation, hyperthermia, mydriasis, muscular aches, vomiting, diarrhea, anxiety, and hostility are effects of

Abstinence syndrome

35

The diagnostic triad of opioid overdosage is

Coma, depressed respiration and miosis

36

Which opioid agents is used in the treatment of acute opioid overdose?

Naloxone

37

Indicate the pure opioid antagonist, which has a half-life of 10 hours

Naltrexone

38

In contrast to morphine, methadone

- Causes tolerance and physical dependence more slowly
- Is more effective orally
- Withdrawal is less severe, although more prolonged

39

Which opioid analgesics is a partial mu receptor agonist?

Buprenorphine

40

Indicate a partial mu receptor agonist, which has 20-60 times analgesic potency of morphine, and a longer duration of action

Buprenorphine

41

Which opioid analgesics is a strong kappa receptor agonist and a mu receptor antagonist?

Nalbuphine

42

Which drugs has weak mu agonist effects and inhibitory action on norepinephrine and serotonin reuptake in the CNS?

Tramadol

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