AGENTS, CONTROLLING THE FUNCTIONS OF THE CENTRAL NERVOUS SYSTEM - Antipsychotic agents Flashcards Preview

Pharmacology > AGENTS, CONTROLLING THE FUNCTIONS OF THE CENTRAL NERVOUS SYSTEM - Antipsychotic agents > Flashcards

Flashcards in AGENTS, CONTROLLING THE FUNCTIONS OF THE CENTRAL NERVOUS SYSTEM - Antipsychotic agents Deck (46):
1

Neuroleptics are used to treat

Psychosis

2

Most antipsychotic drugs

Strongly block postsynaptic d2receptor

3

Which dopaminergic systems is most closely related to behavior?

The mesolimbic and mesofrontal systems

4

Hyperprolactinemia is caused by blockade of dopamine in

The pituitary

5

Parkinsonian symptoms and tarditive dyskinesia are caused by blockade dopamine in

The nigrostriatal system

6

Extrapyramidal reactions can be treated by

Benztropine mesylate

7

True or False. D1 postsynaptic receptors are located in striatum

TRUE

8

True or False. D2 pre- and postsynaptic receptors are located in striatum and limbic areas

TRUE

9

True or False. D4 postsynaptic receptors are located in frontal cortex, mesolimbic system

TRUE

10

Which antipsychotic drugs is typical?

Haloperidol

11

Indicate the atypical antipsychotic drug

Clozapine

12

Atypical antipsychotic agents (such as clozapine) differ from typical ones

- In reduced risks of extrapyramidal system dysfunction and tardive dyscinesia
- In having low affinity for D1 and D2 dopamine receptors
- In having high affinity for D4 dopamine receptors

13

Tardive dyskinesia is the result of

Hyperactive dopaminergic state in the presence of dopamine blockers

14

Which antipsychotic drugs has high affinity for D4 and 5-HT2 receptors?

Clozapine

15

Indicate the antipsychotic drug, which is a phenothiazine aliphatic derivative

Chlorpromazine

16

Indicate the antipsychotic drug, which is a butyrophenone derivative

Droperidol

17

Indicate the antipsychotic drug, which is a thioxanthene derivative

Thiothixene

18

Indicate the antipsychotic agent – a dibenzodiazepine derivative

Clozapine

19

The strong antiemetic effect of the phenothiazine derivatives is due to dopamine receptor blockade

- In the chemoreceptor trigger zone of the medulla
- Of the receptors in the stomach
- The medullar vomiting centre

20

Phenothiazine derivatives are able to

Alter temperature-regulating mechanisms producing hypothermia

21

Most phenothiazine derivatives have

- Antihistaminic activity
- Anticholinergic activity
- Antidopaminergic activity

22

Indicate the antipsychotic drug having significant peripheral alpha-adrenergic blocking activity

Chlorpromazine

23

Indicate the antipsychotic drug having a muscarinic-cholinergic blocking activity

Chlorpromazine

24

Indicate the antipsychotic drug having H1-antihistaminic activity

- Clozapine
- Chlorpromazine
- Olanzapine

25

Parkinson′s syndrome, acute dystonic reactions, tardive dyskinesia, antimuscarinic actions, orthostatic hypotension, galactorrhea are possible adverse effects of

Chlorpromazine

26

Orthostatic hypotension can occur as a result of

- The central action of phenothiazines
- Inhibition of norepinephrine uptake mechanisms
- Alpha adrenoreceptor blockade

27

Adverse peripheral effects, such as loss of accommodation, dry mouth, tachycardia, urinary retention, constipation are related to

Muscarinic cholinoreceptor blockade

28

Which phenothiazine derivatives is a potent local anesthetic?

Chlorpromazine

29

Which phenothiazine derivatives may produce cardiac toxicity, including ventricular arrhythmias, cardiac
conduction block, and sudden death?

Thioridazine

30

Which antipsychotic agents is preferable in patients with coronary and cerebrovascular disease?

Haloperidol

31

Which antipsychotic agents is used in combination with an opioid drug fentanyl in neuroleptanalgesia?

Droperidol

32

The mechanism of haloperidol antipsychotic action is

- Blocking D2 receptors
- Central alpha-adrenergic blocking
- Inhibition of norepinephrine uptake mechanisms

33

True or False about clozapine. Has potent anticholinergic activity

TRUE

34

True or False about clozapine. Has high affinity for D1 and D2 dopamine receptors

FALSE

35

True or False about clozapine. Produces significant extrapyramidal toxicity

FALSE

36

True or False about clozapine. Is related to typical antipsychotic agents

FALSE

37

Which antipsychotic drugs has the high risk of potentially fatal agranulocytosis and risk of seizures at high doses?

Clozapine

38

Which antipsychotic drugs has high affinity for D2 and 5-HT2 receptors?

Risperidone

39

Lithium carbonate is useful in the treatment of

Bipolar disorder

40

The drug of choice for manic-depressive psychosis is

Lithium carbonate

41

The lithium mode of action is

- Effect on electrolytes and ion transport
- Effect on neurotransmitters
- Effect on second messengers

42

True or False about lithium. Stimulate dopamine and beta-adrenergic receptors

FALSE

43

True or False about lithium. Decrease catecholamine-related activity

TRUE

44

True or False about lithium. Stimulate the development of dopamine receptor supersensitivity

FALSE

45

True or False about lithium. Decrease cholinergic activity

FALSE

46

Which adverse effects is associated with lithium treatment?

- Cardiovascular anomalies in the newborn
- Thyroid enlargement
- Nephrogenic diabetes insipidus

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