AGENTS, CONTROLLING THE FUNCTIONS OF THE CENTRAL NERVOUS SYSTEM - Antidepressant agents Flashcards Preview

Pharmacology > AGENTS, CONTROLLING THE FUNCTIONS OF THE CENTRAL NERVOUS SYSTEM - Antidepressant agents > Flashcards

Flashcards in AGENTS, CONTROLLING THE FUNCTIONS OF THE CENTRAL NERVOUS SYSTEM - Antidepressant agents Deck (38):
1

The principal mechanism of action of antidepressant agents is

Blocking epinephrine or serotonin reuptake pumps

2

Which agents is related to tricyclic antidepressants?

Amitriptyline

3

Indicate the second-generation heterocyclic drug

Maprotiline

4

Which agents is related to the third-generation heterocyclic antidepressants?

Nefazodone

5

Which antidepressants is a selective serotonin reuptake inhibitor?

Fluoxetine

6

Which antidepressant agents is a selective inhibitor of norepinephrine reuptake?

Maprotiline

7

Indicate the antidepressant, which blocks the reuptake pumps for serotonin and norepinephrine

Amitriptyline

8

Which antidepressants is an unselective MAO blocker and produces extremely long-lasting inhibition of the enzyme?

Tranylcypramine

9

Indicate the irreversible MAO inhibitor, which is a hydrazide derivative

Phenelzine

10

Which MAO inhibitors has amphetamine-like activity and is related to nonhydrazide derivatives

Tranylcypramine

11

Which antidepressants is a selective short-acting MAO-A inhibitor?

Moclobemide

12

Monoamine Oxydase A

Is responsible for norepinephrine, serotonin, and tyramine metabolism

13

Which synapses are involved in depression?

Serotoninergic synapses

14

Block of which type of Monoamine Oxydase might be more selective for depression?

MAO-A

15

The principal mechanism of MAO inhibitor action is

Blocking a major degradative pathway for the amine neurotransmitters, which permits more amines to accumulate in presynaptic stores

16

The irreversible MAO inhibitors have a very high risk of developing

Hypertensive reactions to tyramine ingested in food

17

The most dangerous pharmacodynamic interaction is between MAO inhibitors and

- Selective serotonin reuptake inhibitors
- Tricyclics
- Sympathomimetics

18

Serotonin syndrome is a result of

- Increased stores of monoamine
- Significant accumulation of amine neurotransmitters in the synapses

19

The therapeutic response to antidepressant drugs is usually over a period of

2-3 weeks

20

Which antidepressants may have latency period as short as 48 hours?

Tranylcypromine

21

Which features do MAO inhibitors and tricyclic antidepressants have in common?

Increase levels of biogenic amines

22

Tricyclic antidepressants are

Mixed norepinephrine and serotonin reuptake inhibitors

23

Which autonomic nervous system effects is common for tricyclic antidepressants?

- Antimuscarinic action
- Antihistaminic action
- Alfa adrenoreceptor-blocking action

24

Indicate an effective antidepressant with minimal autonomic toxicity

Fluoxetine

25

Fluoxetine has fewer adverse effects because of

Minimal binding to cholinergic, histaminic, and alfa-adrenergic receptors

26

Which tricyclic and heterocyclic antidepressants has the greatest sedation?

- Doxepin
- Amitriptyline
- Trazodone

27

Which tricyclic and heterocyclic agents has the least sedation?

Protriptyline

28

Indicate a tricyclic or a heterocyclic antidepressant having greatest antimuscarinic effects

Amitriptyline

29

Indicate a tricyclic or a heterocyclic antidepressant having least antimuscarinic effects

- Trazodone
- Buprorion
- Mirtazapine

30

Which antidepressants has significant alfa2-adrenoreceptor antagonism?

Mirtazapine

31

Indicate the main claim for an ideal antidepressant agent

- A faster onset of action
- Fewer adverse sedative and autonomic effects
- Fewer toxicity when overdoses are taken

32

Sedation, peripheral atropine-like toxicity (e.g. Cycloplegia, tachycardia, urinary retention, and constipation), orthostatic hypotension, arrhythmias, weight gain and sexual disturbances are possible adverse effects of

Amitriptyline

33

Which drugs is least likely to be prescribed to patients with prostatic hypertrophy, glaucoma, coronary and cerebrovascular disease?

Amitriptyline

34

Indicate the antidepressant agent, which is a phenyltolylpropylamine derivative

Fluoxetine

35

The mechanism of fluoxetine action includes

- Selective inhibition of serotonine uptake in the CNS
- Little effect on central norepinephrine or dopamine function
- Minimal binding to cholinergic, histaminic, and alfa-adrenergic receptors

36

Which antidepressants is used for treatment of eating disorders, especially buliemia?

Fluoxetine

37

True or False. Sertaline and paroxetine are similar to fluoxetine in the mechanism of action and therapeutic use, sertaline is less likely to interact adversely with other drugs.

TRUE

38

A highly selective serotonine reuptake inhibitor is

- Sertaline
- Paroxetine
- Fluoxetine

Decks in Pharmacology Class (41):