AGENTS, CONTROLLING THE FUNCTIONS OF THE CENTRAL NERVOUS SYSTEM - Anxiolytic agents Flashcards Preview

Pharmacology > AGENTS, CONTROLLING THE FUNCTIONS OF THE CENTRAL NERVOUS SYSTEM - Anxiolytic agents > Flashcards

Flashcards in AGENTS, CONTROLLING THE FUNCTIONS OF THE CENTRAL NERVOUS SYSTEM - Anxiolytic agents Deck (30):
1

Anxiolytics are used to treat

Neurosis

2

Anxiolytic agents should

Reduce anxiety and exert a calming effect

3

Anxiolytics are also useful for

- Treatment of epilepsy and seizures
- Insomnia
- Muscle relaxation in specific neuromuscular disorders

4

Indicate the agents of choice in the treatment of most anxiety states

Benzodiazepines

5

The choice of benzodiazepines for anxiety is based on

- A relatively high therapeutic index
- Availability of flumazenil for treatment of overdose
- A low risk of physiologic dependence

6

Which anxiolitics is a benzodiazepine derivative

Clordiazepoxide

7

Indicate the benzodiazepine, which has the shortest elimination half-life

Triazolam

8

Which benzodiazepines has the shortest duration of action?

Triazolam

9

Which benzodiazepines is less likely to cause cumulative and residual effects with multiple doses?

Lorazepam

10

Anxiolytic dosage reduction is recommended

- In patients taking cimetidine
- In patients with hepatic dysfunction
- In elderly patients

11

Which benzodiazepines is preferred for elderly patients?

Triazolam

12

Which anxiolytics is preferred in patient with limited hepatic function?

Buspirone

13

Indicate the mechanism of hypnotic benzodiazepine action

Increasing the frequency of Cl- channel opening events

14

Which anxiolytics is a partial agonist of brain 5-HT1A receptors?

Buspirone

15

Indicate the competitive antagonist of BZ receptors

Flumazenil

16

Indicate the agent, which interferes with GABA binding

Bicuculline

17

Antianxiety agents have

- Sedative and hypnotic activity
- Muscle relaxing and anticonvulsant effects
- Amnesic properties

18

Which disadvantages does not limit using benzodiazepines as antianxiety agents?

A high risk of drug interactions based on liver enzyme induction

19

Indicate the anxiolitic agent, which relieves anxiety without causing marked sedative effects

Buspirone

20

Which anxiolytics has minimal abuse liability?

Buspirone

21

In contrast to benzodiazepines, buspirone

Causes less psychomotor impairment and does not affect driving skills

22

Which sedative-hypnotic drugs does not potentiate the CNS depressant effects of ethanol, phenothiazines, or tricyclic antidepressants?

Buspirone

23

Limitation of buspirone is

An extremely slow onset of action

24

Which drugs may be used as antianxiety agents?

- BETA-blocking drugs
- Clonidine - a partial agonist of alfa2 receptors
- Tricyclic antidepressants

25

Which benzodiazepines is more likely to cause “hangover” effects such as drowsiness, dysphoria, and mental or motor depression the following day?

Clorazepat

26

Additive CNS depression can be predicted if benzodiazepines are used with

- Ethanol
- Morphine
- Clorpromazine

27

Which dosage of benzodiazepines for 60-90 days may produce severe withdrawal symptoms?

50-60 mg/d

28

Restlessness, anxiety, orthostatic hypotension, generalized seizures, severe tremor, vivid hallucination, and psychosis are possible symptoms of

Withdrawal

29

Flumazenil is used to

- Reverse the CNS depressant effects of hypnotic benzodiazepines overdose
- Hasten recovery following use of hypnotic benzodiazepines in anesthetic and diagnostic procedure
- Reverse benzodiazepine-induced respiratory depression

30

Flumazenil given intravenously

Acts rapidly but has a short half-life

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