AGENTS, CONTROLLING THE FUNCTIONS OF THE PERIPHERAL NERVOUS SYSTEM - Cholinomimetic drugs Flashcards Preview

Pharmacology > AGENTS, CONTROLLING THE FUNCTIONS OF THE PERIPHERAL NERVOUS SYSTEM - Cholinomimetic drugs > Flashcards

Flashcards in AGENTS, CONTROLLING THE FUNCTIONS OF THE PERIPHERAL NERVOUS SYSTEM - Cholinomimetic drugs Deck (45):
1

Acetylcholine is not a specific neurotransmitter at

Sympathetic postganglionic nerve endings

2

Acetylcholine is a specific neurotransmitter at

- Sympathetic ganglia
- Parasympathetic ganglia
- Parasympathetic postganglionic nerve endings

3

Muscarinic receptors are located in

Autonomic effector cells

4

Indicate the location of M2 cholinoreceptor type

Heart

5

The symptoms of mushroom poisoning include

- Salivation, lacrimation, nausea, vomiting
- Headache, abdominal colic
- Bradycardia, hypotension and shock

6

The symptoms of mushroom poisoning include all of the following EXCEPT

Dryness of mouth, hyperpyrexia, hallucination

7

Which cholinomimetics activates both muscarinic and nicotinic receptors?

Bethanechol

8

Indicate a cholinomimetic agent, which is related to direct-acting drugs

Carbachol

9

Characteristics of carbachol include

- It decreases intraocular pressure
- It exerts both nicotinic and muscarinic effects
- It is resistant to acethylcholiesterase

10

Characteristics of carbachol include all of the following EXCEPT

It causes mydriasis

11

Acetylcholine is not used in clinical practice because

It is very rapidly hydrolyzed.

12

Parasympathomimetic drugs cause

Bradycardia

13

Which direct-acting cholinomimetics is mainly muscarinic in action?

Bethanechol

14

Which direct-acting cholinomimetics has the shortest duration of action?

Acetylcholine

15

Bethanechol has all of the following properties

- It is extremely resistant to hydrolysis
- Purely muscarinic in its action
- It is used for abdominal urinary bladder distention

16

Bethanechol has all of the following properties EXCEPT

It exerts both nicotinic and muscarinic effects

17

A M-cholinimimetic agent is

Pilocarpine

18

Characteristics of pilocarpine include

- It is a tertiary amine alkaloid
- It causes miosis and a decrease in intraocular pressure
- It is useful in the treatment of glaucoma

19

Characteristics of pilocarpine include all of the following EXCEPT

Causes a decrease in secretory and motor activity of gut

20

Which cholinomimetics is a plant derivative with lower potency than nicotine but with a similar spectrum of action?

Lobeline

21

Which cholinomimetics is indirect-acting?

Edrophonium

22

The mechanism of action of indirect-acting cholinomimetic agents is

Inhibition of the hydrolysis of endogenous acetylcholine

23

Indicate a reversible cholinesterase inhibitor

Physostigmine

24

Which cholinesterase inhibitors is irreversible?

Isoflurophate

25

Indicate cholinesterase activator

Pralidoxime

26

Isofluorophate increases all of the following effects except

Bronchodilation

27

Isofluorophate increases all of the following effects

- Lacrimation
- Muscle twitching
- Salivation

28

Indicate a cholinesterase inhibitor, which has an additional direct nicotinic agonist effect

Neostigmine

29

Сholinesterase inhibitors do not produce

Dramatic hypertension and tachycardia

30

Сholinesterase inhibitors produce

- Bradycardia, no change or modest fall in blood pressure
- Increased strength of muscle contraction, especially in muscles weakened by myasthenia gravis
- Miosis and reduction of intraocular pressure

31

Which cholinomimetics is commonly used in the treatment of glaucoma?

Pilocarpine

32

Indicate the organophosphate cholinesterase inhibitor, which can be made up in an aqueous solution for ophthalmic use and retains its activity within a week:

Echothiophate

33

Which cholinomimetics is most widely used for paralytic ileus and atony of the urinary bladder?

Neostigmine

34

Chronic long-term therapy of myasthenia is usually accomplished with

Neostigmine

35

Which cholinomimetics is a drug of choice for reversing the effects of nondepolarizing neuromuscular relaxants?

Edrophonium

36

Indicate the reversible cholinesterase inhibitor, which penetrates the blood-brain bar

Physostigmine

37

Which cholinomimetics is used in the treatment of atropine intoxication?

Physostigmine

38

The symptoms of excessive stimulation of muscarinic receptors include

- Abdominal cramps, diarrhea
- Increased salivation, excessive bronchial secretion
- Miosis, bradycardia

39

The symptoms of excessive stimulation of muscarinic receptors include all of the following EXCEPT

Weakness of all skeletal muscles

40

The excessive stimulation of muscarinic receptors by pilocarpine and choline esters is blocked competitively by:

Atropine

41

The toxic effects of a large dose of nicotine include

- Convulsions, coma and respiratory arrest
- Skeletal muscle depolarization blockade and respiratory paralysis
- Hypertension and cardiac arrhythmias

42

The toxic effects of a large dose of nicotine include all of the following EXCEPT

Hypotension and bradycardia

43

The dominant initial sights of acute cholinesterase inhibitors intoxication include

- Salivation, sweating
- Bronchial constriction
- Vomiting and diarrhea

44

The dominant initial sights of acute cholinesterase inhibitors intoxication include all of the following except

Mydriasis

45

Which drugs is used for acute toxic effects of organophosphate cholinesterase inhibitors?

Pralidoxime

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