AGENTS, CONTROLLING THE FUNCTIONS OF THE PERIPHERAL NERVOUS SYSTEM - Adrenoreceptor antagonist drugs Flashcards Preview

Pharmacology > AGENTS, CONTROLLING THE FUNCTIONS OF THE PERIPHERAL NERVOUS SYSTEM - Adrenoreceptor antagonist drugs > Flashcards

Flashcards in AGENTS, CONTROLLING THE FUNCTIONS OF THE PERIPHERAL NERVOUS SYSTEM - Adrenoreceptor antagonist drugs Deck (67):
1

Which drugs is a nonselective alfa receptor antagonist?

Phentolamine

2

Indicate the alfa1-selective antagonist

Prazosin

3

Which agents is an alfa2–selective antagonist?

Yohimbine

4

Indicate the irreversible alfa receptor antagonist

Phenoxybenzamine

5

Which drugs is an nonselective beta receptor antagonist?

Propranolol

6

Indicate the beta1-selective antagonist

Metoprolol

7

Which of the following agents is a beta2–selective antagonist?

Butoxamine

8

Indicate the beta adrenoreceptor antagonist, which has partial beta–agonist activity

Pindolol

9

Which drugs is a reversible nonselective alfa, beta antagonist?

Labetalol

10

Indicate the indirect-acting adrenoreceptor blocking drug

Reserpine

11

The principal mechanism of action of adrenoreceptor antagonists is

Reversible or irreversible interaction with adrenoreceptors

12

Characteristics of alfa-receptor antagonists include

- They cause a fall in peripheral resistance and blood pressure
- They cause epinephrine reversal (convert a pressor response to a depressor response)
- They may cause postural hypotension and reflex tachycardia

13

Characteristics of alfa-receptor antagonists do not include

Bronchospasm

14

Which drugs is an imidazoline derivative and a potent competitive antagonist at both alfa1 and alfa2 receptors?

Phentolamine

15

Characteristics of phentolamine include

- Reduction in peripheral resistance
- Tachycardia
- Stimulation of muscarinic, H1 and H2 histamine receptors

16

Characteristics of phentolamine do not include

Stimulation of responses to serotonin

17

The principal mechanism of phentolamine-induced tachycardia is

Antagonism of presynaptic alfa2 receptors enhances norepinephrine release, which causes cardiac stimulation via unblocked beta receptors

18

Nonselective alfa-receptor antagonists are most useful in the treatment of

Pheochromocytoma

19

The main reason for using alfa-receptor antagonists in the management of pheochromocytoma is

Blockade of alfa2 receptors on vascular smooth muscle results in epinephrine stimulation of unblocked alfa2 receptors

20

Which drugs is useful in the treatment of pheochromocytoma?

Phentolamine

21

Indicate adrenoreceptor antagonist agents, which are used for the management of pheochromocytoma

Αlfa-receptor antagonists

22

The principal adverse effects of phentolamine include

- Diarrhea
- Arrhythmias
- Myocardial ischemia

23

The principal adverse effects of phentolamine do not include

Bradycardia

24

Indicate the reversible nonselective alfa-receptor antagonist, which is an ergot derivative

Ergotamine

25

Indicate an alfa-receptor antagonist, which binds covalently to alfa receptors, causing irreversible blockade of long duration (14-48 hours or longer)

Phenoxybenzamine

26

Compared with phentolamine, prazosin has all of the following features

- Highly selective for alfa1 receptors
- The relative absence of tachycardia
- Persistent block of alfa1 receptors

27

Compared with phentolamine, prazosin has not features

Irreversible blockade of alfa receptors

28

True or False. ALFA1a subtype mediates both vascular and prostate smooth muscle contraction

FALSE

29

True or False. There are at least three subtypes of alfa1 receptors, designated alfa1a, alfa1b and alfa1d

TRUE

30

True or False. ALFA1a subtype mediates prostate smooth muscle contraction

TRUE

31

True or False. ALFA1b subtype mediates vascular smooth muscle contraction

TRUE

32

Indicate an alfa1 adrenoreceptor antagonist, which has great selectivity for alfa1a subtype

Tamsulosin

33

Subtype-selective alfa1 receptor antagonists such as tamsulosin, terazosin, alfusosin are efficacious in

Benign prostatic hyperplasia (BPH)

34

Indicate an alfa receptor antagonist, which is an efficacious drug in the treatment of mild to moderate systemic hypertension

Prazosin

35

Which alfa receptor antagonists is useful in reversing the intense local vasoconstriction caused by inadvertent infiltration of norepinephrine into subcutaneous tissue during intravenous administration?

Phentolamine

36

Beta-blocking drugs-induced chronically lower blood pressure may be associated with theirs effects on

- The heart
- The blood vessels
- The renin-angiotensin system

37

Characteristics of beta-blocking agents include

- They occupy beta receptors and competitively reduce receptor occupancy by catecholamines or other beta agonists
- They do not cause hypotension in individuals with normal blood pressure
- They can cause blockade in the atrioventricular node

38

Characteristics of beta-blocking agents do not include

They induce depression and depleted stores of catecholamines

39

Beta-receptor antagonists have all of the following cardiovascular effects

- The negative inotropic and chronotropic effects
- Vasoconstriction
- Reduction of the release of renin

40

Beta-receptor antagonists have not the following cardiovascular effects

Acute effects of these drugs include a fall in peripheral resistance

41

Beta-blocking agents have all of the following effects

- Bronchoconstriction
- Decrease of aqueous humor prodaction
- “membrane-stabilizing” action

42

Beta-blocking agents have all of the following effects except

Increase plasma concentrations of HDL and decrease of VLDL

43

Beta-receptor antagonists cause

Inhibition of glycogenolysis

44

Propranolol has all of the following cardiovascular effects

- It decreases cardiac work and oxygen demand
- It inhibits the renin secretion
- It increases the atrioventricular nodal refractory period

45

Propranolol has all of the following cardiovascular effects except

It reduces blood flow to the brain

46

Propranolol-induced adverse effects include

- Bronchoconstriction
- “supersensitivity” of beta-adrenergic receptors (rapid withdrawal)
- Sedation, sleep disturbances, depression and sexual dysfunction

47

Propranolol-induced adverse effects do not include

Hyperglycemia

48

Propranolol is used in the treatment all of the following diseases

- Cardiovascular diseases
- Hyperthyroidism
- Migraine headache

49

Propranolol is used in the treatment all of the following diseases except

Bronchial asthma

50

Metoprolol and atenolol are members of

The beta1-selective group

51

Which beta receptor antagonists is preferable in patients with asthma, diabetes or peripheral vascular diseases?

Metoprolol

52

Indicate a beta receptor antagonist, which has very long duration of action

Nadolol

53

Indicate a beta1-selective receptor antagonist, which has very long duration of action

Betaxolol

54

Which drugs is a nonselective beta-blocker without intrinsic sympathomimetic or local anesthetic activity and used for the treatment of life-threatening ventricular arrhythmias?

Sotalol

55

Indicate a beta receptor antagonist with intrinsic sympathomimetic activity

Oxprenolol

56

Pindolol, oxprenolol have all of the following properties

- They are nonselective beta antagonists
- They are less likely to cause bradycardia and abnormalities in plasma lipids
- They are effective in hypertension and angina

57

Which drugs has both alfa1-selective and beta-blocking effects?

Labetalol

58

Characteristics of carvedilol include

- It has both alfa1-selective and beta-blocking effects
- It attenuates oxygen free radical-initiated lipid peroxidation
- It inhibits vascular smooth muscle mitogenesis

59

Characteristics of carvedilol do not include

It is a beta1-selective antagonist

60

Indicate the adrenoreceptor antagonist drug, which is a rauwolfia alkaloid

Reserpine

61

Characteristics of reserpine include

- It decreases cardiac output, peripheral resistance and inhibits pressor reflexes
- It may cause a transient sympathomimetic effect
- It depletes stores of catecholamines and serotonin in the brain

62

Characteristics of reserpine do not include

It inhibits the uptake of norepinephrine into vesicles and MAO

63

Indicate a beta-blocker, which is particularly efficacious in thyroid storm

Propranolol

64

Beta-receptor blocking drugs are used in the treatment all of the following diseases

- Hypertension, ischemic heart disease, cardiac arrhythmias
- Glaucoma
- Hyperthyroidism

65

Beta-receptor blocking drugs are used in the treatment all of the following diseases except

Pheochromocytoma

66

Beta-blocker-induced adverse effects include

- Bronchoconstriction
- Depression of myocardial contractility and excitability
- “supersensitivity” of beta-receptors associated with rapid withdrawal of drugs

67

Beta-blocker-induced adverse effects do not include

Hyperglycemia

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