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Jason's Neuro Block > Aging & Frailty > Flashcards

Flashcards in Aging & Frailty Deck (24):
0

Rectangularisation of survival curves means?

compressing mortality

1

Robert Butler coined term:

Ageism

2

Cellular senescence is?

cells lose ability to divide

3

what causes cellular senescence?

DNA damage, Telomeres, apotosis

4

older people have decreased what to respond to challenges?

reserve

5

How is homeostasis in elderly person?

harder to maintain

6

what is successful ageing?

changes due only to the aging process and not disease or other factors

7

what is usual ageing?

combined effects of aging and disease and environment/lifestyle

8

Frailty is diminished ability to do what?

carry out ADLs

9

Frailty and stress?

harder to respond, reduced capacity, easier to unbalance

10

Frailty as a clinical syndrome?

low-grade inflammatory response

11

What biomarkers is frailty associated with?

IL-6 and TNFa, C-reactive protein

12

IL-6 is predictive of?

functional decline/muscle mass

13

what is sarcopenia?

decreased muscle mass due to altered CNS/PNS, hormones, cytokines, disuse

14

when does skeletal muscle mass start to decline?

3rd decade

15

what muscle type loses faster?

Type 2 > Type 1

16

What is Fried's Frailty Criteria? 5

1. unintentional weight loss
2. weakness
3. exhaustion
4. slow walking speed
5. low physical activity

17

Co-morbidity def'n?

>2 chronic diseases

18

Disability is defined as?

physical or mental impairment that limits >1 major ADL

19

Frailty definition?

high vulnerability to adverse health outcomes

20

Co-morbidity health care implications?

harder to coordinate, polypharmacy, fragmentaion

21

medical syndrome is?

grouping of multiple symptoms to have single dx or disease

22

geriatric syndrome is?

accumulated effect of impairments in multiple domains = adverse outcome
multiple morbid processes

23

5 Giants of Geriatric MEdicine?

Incontinence
Immobility
Impaired balance
Impaired cognition (delirium/dementia)
iatrogenic