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PHM 701 > Alcoholism > Flashcards

Alcoholism Flashcards

1
Q

Type I

A

gradual

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2
Q

Type II

A

early onset

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3
Q

Lab values for alcoholic

A

MCV
High GGT
High AST / ALT
High uric acid
High TG
EtG and Ets

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4
Q

Ethanol ____ GABA

A

stimulates

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5
Q

Ethanol ____ NMDA

A

inhibits

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6
Q

Ethanol ___ dopamine

A

increases

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7
Q

Ethanol ___ opioid peptide

A

activates

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8
Q

Alcohol is a ___

A

depressants

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9
Q

Chronic use of alcohol effects GABA receptor by __

A

down regulation
abruptly quitting means less inhibitory NT

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10
Q

Chronic use of alcohol effects NMDA receptor by __

A

up regulation
abruptly quitting means more stimulation

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11
Q

Alcohol messes with ____ parts of brain first

A

most complex

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12
Q

Chronic alcohol use can cause

A

Addiction
Wernicke-Korsakoff
Cortical atrophy / Dementia
Hepatic
Pancreatic

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13
Q

Wernicke-Korsakoff syndrome caused by

A

Wernicke’s encephalopathy

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14
Q

Signs of Korsakoff

A

anterograde amnesia, hallucinations

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15
Q

PK of ethanol

A

lipid and water soluble
non protein bound
first order absorption
zero order elimination
capacity limited metabolism
gastric emptying increases absorption

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16
Q

Delirium tremens

A

disordered consciousness
last 1-5 days
mortality risk
hallucinations, disorientation, tachy

17
Q

Treatment for ethanol withdrawal

A

Thiamine 50-100mg daily
D5 and 1/2 NS
multivitamin
Standing clonidine and benzo

18
Q

Types of regimens for alcohol withdrawal

A

symptom triggered - Diazepam/Lorazepam q1 hr

fixed schedule - diazepam/lorazepam q 6hrs

19
Q

Therapy in abstinence

A

Disulfiram
Naltrexone
Acamprosate

20
Q

Disulfiram MOA

A

blocks aldehyde dehydrogenase cause buildup of acetyl CoA when drink

21
Q

Naltrexone MOA

A

competitive antag at opioid receptor

22
Q

Acamprosate MOA

A

inc. activity of GABA and dec, glutamate (mimics alcohol effects)

PHM 701 (7 decks)

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