Aldosterone Antagonists Flashcards Preview

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Flashcards in Aldosterone Antagonists Deck (16)
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1

Example

Spironolactone

2

Indications

- Hypertension
- Heart failure
- Primary hyperaldosteronism
- Hepatic failure with ascites

3

What is ascites?

- Abnormal fluid occumulation in the peritoneal cavity

4

What are the contraindications of spironolactone?

- Hyperkalaemia
- Hyponatraemia
- Addisons disease

5

Cautions

- Porphyria
- Renal impairment
- Hepatic impairment
- Pregnancy and breast feeding

6

What is porphyria?

- A disease in which porphyrins build up
- Affects skin or nervous system

7

How do aldosterone antagonists inhibit the actions of aldosterone?

- Prevent aldosterone binding to its receptor

8

What does the prevention of aldosterone from binding to its receptor cause?

- Reduced sodium reabsorption
- Causes loss of Na and water
- Reduces potassium excretion

9

Why is the diuretic effect of spironolactone weak?

- Only 2% or reabsorbed sodium done through aldosterone

10

What systemic effect will the reduction of aldosterone cause?

- Reduction in blood pressure

11

How is spironolactone administered?

- Oral

12

What adverse reactions can occur with spironolactone?

- Hyperkalaemia
- Gynaecomastia
- Impotence
- Menstrual irregularities
- Hepatotoxicity

13

What drugs does spironolactone interact with?

Those that increase potassium

- ACE-I
- Angiotensin II antagonists
- Potassium sparing diuretics

Use with these will cause hyperkalaemia (may also occur with NSAIDs)

14

What can spironolactone cause with relation to digoxin?

- Can increase plasma digoxin levels

15

What can spironolactone cause with regards to lithium

Can decrease lithium excretion leading to toxicity

16

What should aldosterone antagonists NOT be prescribed with

K supplements