Flashcards in alzheimers Deck (12)
common causes of dementia?
lewy body dementia
common frontotemporal dementia?
function of apoprotein E4?
encodes a cholesterol transport protein
in alzheimers, you get widespread cerebral atrophy, affecting mainly?
hippocampus and cortex
microscopically, the deposition of plaques and neurofibrillary tangles due to?
played are due to A beta amyloid protein and neurofibrillary tangles are abnormal aggregations of tau proteins
in AD, tau proteins are excessively?
what are neurofibrillary tangles?
paired helical filaments are partly made from a protein called tau
the three acetylcholinesterase inhibitors used in AD?
donepizil, galantamine and rivastagmine
moderate Alzheimer's who are intolerant of, or have a contraindication to, acetylcholinesterase inhibitors. what are they given?
what drug class is mimentidine?
a NMDA receptor antagonist
how do you differentiate lewey body dementia from others?
Association with parkinsonism (Lewey bodies found in parkinson as well)
causes visual hallucinations (often unpleasant and persecutory)