Aminogycosides & Anti-TB Drugs Flashcards Preview

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Flashcards in Aminogycosides & Anti-TB Drugs Deck (18):
1

What drugs are rapidly bacteriocidal?

aminoglycosides

2

What is an aminoglycoside is most commonly used?

Gentomyacin

3

What antibiotic:

primarily used in aerobic, Gram -  bacteria
 

Aminoglycosides

4

What are the side effects of aminoglycosides? (2)

Ototoxicity, irreversible

Nephrotoxicity, reversible

5

What 2 antibiotics should never be mixed in the same vial?

Aminoglycosides and PCNs!

6

What are some aminoglycosides? (5)

Gentamicin

Streptomycin

Amikacin

Neomycin

Kanamycin

7

What aminoglycoside:

1st discovered 
Primarily used to treat multidrug resistant TB
Very toxic
Treats bacterial endocarditis

Streptomycin

8

What aminoglycoside:

Topical only for infections of skin, mucous

Neomycin

9

What aminoglycoside:

Preferred for P. aeruginosa infections

Gentomycin

10

What aminoglycoside:

Effective in infections with organisms resistant to gentamicin

Semi-synthetic

Most expensive 


 

Amikacin

11

Mycobacterium tuberculosis, the microorganism that causes TBt survives within _________.

macrophages

12

What anti-TB drug inhibits mycolic acid?

Isoniazid

13

What is the DOC (in combination with another drug) for TB?

Isoniazid

14

What anti-TB drug:

Broad spectrum
Mostly Gram +
Inhibits RNA synthesis (RNA polymerase)
 

Rifampin

15

What 2 anti-TB drugs are the most highly effective combinations?

Isoniazid

Rifampin

16

What anti-TB:

causes induction of hepatic metabolizing enzymes thus enhancing metabolism of many other drugs, such as warfarin,glucocorticoids, oral contraceptives

Rifampin

17

What anti-TB drug:

Inhibits mycobacterial arabinosyl transferases 

Ethambutol (Myambutol®)

18

Combination therapy of multidrugs for TB is mandatory.  True or false?

True