Amyloidosis Flashcards
(24 cards)
pathologic aggregate of amyloid proteins (damages tissues)
Amyloid
beta amyloid buildup seen in what
Alzheimers
Amylin deposits in pancreas
type II diabetes
diffuse amyloid deposition
amyloidosis
AL: light chains
primary amyloidosis
AA: serum amyloid A
secondary amyloidosis
beta-2 microglobulin in ____-related amyloidosis
dialysis-related amyloidosis
transthyretin seen in ____-related systemic amyloidosis
age-related
normal transthyretin seen in what amyloidosis
age-related
abnormal transthyretin seen in what
familial (hereditary) amyloidosis
pink on a standard biopsy
amyloid
congo red stain: pink under ordinary light
amyloid
congo red stain: shows apple-green birefringence under polarized light
amyloid
amyloid forms _____ sheets that is responsible for congo red staining
beta-pleated
plasma cell malignancy
amyloid formed from light chains
monoclonal plasma cells on bone marrow biopsy
AL Amyloidosis
occurs in chronic inflammatory conditions (RA, ankylosing spondylitis, IBD)
serum amyloid A proteins (SAA)
AA amyloidosis
B2 microglobulin
complication of renal failure
dialysis does not effectively remove B2 microglobulin
shoulder pain
carpal tunnel syndrome
Dialysis-related Amyloidosis
pt on dialysis develops pain in shoulder and/or wrist
Dialysis-related amyloidosis
Age-related amyloidosis
pt born with this but takes years for amyloid to buildup and sx’s to occur
Familial Amyloidosis
rare
Amyloidosis
most commonly involved organ: kidneys
leads to proteinuria and nephrotic syndrome
Amyloidosis
in the heart, leads to restrictive cardiomyopathy and arrhythmias
Amyloidosis
how to biopsy for Amyloidosis
abdominal fat pad
