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Flashcards in Anaemia Deck (16):
1

What will Fe studies of a Fe deficit patient show?

Low ferritin

Low Transferrin saturation

Low Fe

Normal or high transferrin

1

How do you differentiate Fe deficiency anaemia and thalassemia minor on FBE?

For the same degree of microcytosis, the Hb concentration is spared and the cell count remains normal in thal minor cf to Fe deficiency

2

Why might a haemolysis not be picked up in FBE?

Because compensatory erythropoiesis is maintaining Hb

3

What are the five tests that are abnormal in haemolysis?

Blood film

Lactate dehydrogenase

Hyperbilirubinaemia (unconjugated)

Reticulocytosis

Depressed haptoglobins (to pick up the products of haemolysis)

3

Does finding no HbH  in parents exclude thalassaemia major developing in children?

No, both may be aa/- - where HbH test is not sensitive enough

3

What are porphyrias?

Disorders of haem

5

Why do anaemia's of inflammation develop?

Because inflammatory mediators depress EPO or elevate hepcidin

6

What is HbH?

Hb with a beta chain tetramer - no O2 carrying capacity but diagnostic of alpha thalassemia

9

What is the function of transferrin in Fe balance?

Transport Fe

10

What is the function of ferritin in Fe balance?

Store Fe

11

How will the blood film appear in B12 deficiency?

Macrocytic RBCs

Some ovular RBCs

Hypersegmented neutrophils

Cytopenia of other blood cell types

12

How does myelofibrosis cause anaemia?

Scar tissue replaces haematopoiesis

13

What is myelodysplasia?

Disorder or inefficient haematopoiesis

14

How does the anaemia caused by occult GIT bleed evolve over time?

Starts with normocytic anaemia then changes to microcytic, hypochromatic as Fe stores are depleted

15

What do anaemia's of chronic disease show on Fe studies?

Transferrin is low

Ferritin is high

16

What are the board causes of haemolysis?

Intrinsic

- Enzymatic eg G6PD deficiency

- Membrane eg hereditory spirocytosis

- Hb eg sickle cell

Extrinsic

- Immune

- Non-immune eg HUS, mechanical