Anaemia Flashcards Preview

Hugh's MD2 Core Conditions and Presentations > Anaemia > Flashcards

Flashcards in Anaemia Deck (27):
1

What does spherocytes on the blood film mean possibly?

Warm haemolytic anaemia

Hereditary spherocytosis

 

2

Which part of the Hb is affected in thalessemia?

Globin

3

What are pencil cells?

A feature of iron deficiency anaemia

(Not in thalessemia)

4

Will an upper GI bleed cause a positive faecal occult blood test?

Yes

5

What is diagnostic test for thalassemia?

Haemoglobin electrophoresis

6

What are some causes of microcytic anaemia?

Fe deficiency

Thalassemia

Chronic disease

Inherited spherocytic

Lead poisoning

7

What is the RDW in Fe deficiency and thal minor?

Fe - elevated

Thal - normal

8

What is a systematic way to classify causes of anaemia?

Blood loss

Decreased production

Increased destruction

9

How long do B12 stores last?

18 months

10

In terms of the classification of anaemia's, what types of anaemia is Fe deficiency anaemia?

Blood loss

Decreased production

11

Does the urine go dark in haemolysis?

Generally no as it won't pass through the glomerulus

12

How long does the folate stores last?

3 months

13

What is the next test to be performed with spherocytes are seen? How is it interrupted?

Direct combs test

- Positive: warm haemolytic anaemia

- Negative: hereditary spherocytosis

14

What is the Ix reticulocyte count useful for?

Determining the function of the bone marrow

15

Where is Fe absorbed? How much can be absorbed per day?

Duodenum

1mg per day

16

What is the size of cells in folate and B12 deficiency?

Macrocytic

17

What is the most common cause of Fe deficiency in Australia?

Occult blood loss from the GIT

18

In haemolysis, is the bilirubin conjugated or unconjugated?

Unconjugated

19

Why might the platelets be up in a patient with fatigue?

Platelets can be elevated in Fe deficiency anaemia

A inflammatory process might be elevating the platelets

20

What abnormal cells might be seen in thalassemia?

Target cells

 

21

What does a leukoerythroblastic picture in peripheral blood reflect?

Bone marrow invasion pushing bone marrow precursors into the peripheral blood

22

What do you look for on blood film in haemolysis?

Spherocytes = warm autoimmune anaemia or hereditary spherocytosis

Fragments + Schistocytes = microangiopathy

Bite cells + blisters = oxidative damage

 

23

What is the red cell distribution width (RDW)?

The width of the peak of the standard deviation of the RBC number and MCV

24

What are the five signs of haemolytic anaemia

Abnormal blood film

Raised lactate dehydrogenase

Raised reticulocyte counts

Raised unconjugated bilirubin

Reduced haptoglobin

25

What must you be wary of when looking at the ferritin in iron studies?

It's an acute phase reactant therefore may be inappropriately normal

26

What test will measure long term folate levels?

Red cell folate

27

What causes decreased RBC production?

Anaemia of chronic disease

Low haematinitcs - Folate, B12, iron

Bone marrow failure

Endocrine disorders - Thyroid, low EPO

Infectious eg TB, HIV