Androgen disease Flashcards
1
Q
Signs suggestive of androgen deficiency in men?
A
Depends on age of onset
In utero:
- Partial virilisation
- Ambiguous genitals
- Complete deficiency/insenstivity –> female genitalia
Puberty:
- Micropenis
- Crypto-orchidism
- Incomplete pubertal maturation
- Eunuchoidal body habitus
Adults:
- Crypto-orchidism
- OP
- DM
- Anaemia
2
Q
Causes of primary androgen insufficiency
A
- Acquired = testicular damage
- Congenital = genetic
- -> klinefelters
- -> androgen insensitivty
- -> CAH
- -> myotnic dystrophy
3
Q
Causes of secondary androgen insufficiency
A
Pituitary/hypothalamic:
- Tumours
- Infiltration
- Trauma
Genetic: Kalimanns
Morbid obesity
Cushings syndrome
Transient:
- Acute illness
- Chronic disease
- Drugs
4
Q
Effect of exogenous testosterone on testosterone deficiency?
A
Increase in muscle mass
