Androgen drugs Flashcards
(23 cards)
What route is testosterone admn?
IM/transdermal
NOT oral
what are testosterone esters
testosterone cypionate and enanthate
Orally effective testosterone
17a-alkylated testosterone
examples of 17a-alkylated testosterone
Methyltestosterone
Fluoxymesterone
Stanazolol (derivative)
Greatest risk of hepatotoxicity
association with jaundice
Methyltestosterone
Fluoxymesterone
MOA
Danazol
depress the preovulatory surge in output of FSH and LH –> reduction in ovarian estrogen and progesterone production , supressed midcycle surge leading to anovulation
Used for endometriosis
Danazol
Leuprolide
synthetic testosterone derivative with high anabolic to androgenic ratio
Oxandrolone
use of oxandrolone
weight gain in ptns who cannot gain weight
Antiandrogens
Finasteride
Dutasteride
Leuprolide
Fltuamide
MOA
Finasteride, dutasteride
reduce levels of DHT by inhibiting 5a-reductase (conversion of testosterone to DHT)
Which antiandrogen is selective for type 2 5a-reductase
Finasteride
a1-adrenergic receptor inhibitors
Tamsulosin
Alfuzosin
MOA
Tamsulosin/Alfuzosin
decrease smooth muscle tone in the prostate and bladder neck
Do a1-adrenergic receptor inhibitors adress the cause of BPH?
no
ADR antiandorgens
gynecomastia
lower PSA levels in males
moa Leuprolide
GnRH agonist –> down regulation of LH and FSH, decreased levels of circulating testosterone in males
Elevated liver function test and gynecomastia
Fltuamide
used for benign prostatic hyperplasia
Finasteride, Dutasteride
used for prostatic cancer
Leuprolide
Fltuamide
Contraindicated for prostate cancer
Stanazolol
Oxandrolone
17a-alkylated testosterone (methyltestosterone, fluoxymesterone)
Contraindications for all testosterone analogs
Prostate cancer
Male breast cancer
Pregnancy
Increases mRNA levels and protein levels of C1 INH and C4… used for?
Stanazolol
used for hereditary angioedema
