Androgens, HPA axis drugs, SH antagonist Flashcards Preview

Pharmacology > Androgens, HPA axis drugs, SH antagonist > Flashcards

Flashcards in Androgens, HPA axis drugs, SH antagonist Deck (20):
1

Leuprolide

Prostate cancer, endometriosis, Central precocious puberty, hypogonadotrophic hypogonadism, prevents premature LH surges (controlled ovulation stimulation)

Agonist to GnRH receptors; downregulation when given continuously, stimulation when puslatile

Can cause hypogonadism w/ continuous treatment

2

Ganirelix

Prevents premature LH surges (controlled ovulation stimulation), prostate cancer

Antagonist at GnRH receptor

Can cause hypogonadism w/ continuous treatment

3

Urofollitropin

Ovulation hyperstimulation

Mimics FSH

Can cause ovarian hyperstimulation syndrome (ovaries become swollen and painful); multiple pregnancies

4

Placental hCG

Initiates ovulation, male infertility

Mimics LH

Can cause ovarian hyperstimulation syndrome (ovaries become swollen and painful); multiple pregnancies

5

Menotropins (hMG)

Use in ovulation hyperstimulation and male infertility

Mimics FSH and LH

Can cause ovarian hyperstimulation syndrome (ovaries become swollen and painful); multiple pregnancies

6

Bromocriptine

Parkinson's Disease, Hyperprolacitinemia

Agonist at DA receptors

GI disturbance, Hypotension, Psych disturbance, ergotism at high doses (Convulsive symptoms and vasoconstriction in extremeties)

7

Oxytocin

Increased uterine contractions

8

Methyltestosterone, oxandrolone

Male hypogonadism, reverse protein loss after surgery or trauma, illicit use in athletes

Steroid receptor

Masculinization, acne, gynecomastia, dec sperm count, premature closure of epiphysis, hepatic dysfunction, cholestatic jaundice, aggression

9

Flutamide

Prostate cancer, BPH flare

Androgen receptor antagonist

Hepatic failure, hot flashes, gynecomastia

10

Finasteride

BPH, male pattern baldness

5-alpha reductase inhibitor, blocks conversion to dyhydrotestosterone

loss of libido, ED

11

Spironolactone

Hypertension, edema, hypokalemia, hirsutism, hyperaldosteronism, PCOS

Androgen receptor antagonist, aldosterone receptor antagonist

Hyperkalemia, metabolic acidosis, gynecomastia

12

Ketoconozole

Androgen receptor positive prostate cancer, Cushing's, anti-fungal

Inhibits steroid synthesis at higher concentrations, anti-fungal drug

Loss of libido, gynecomastia, GI distress, hepatic dysfunction

13

Tamoxifen

Hormone responsive breast cancer, osteoporosis

Estrogen R antagonist at breast and agonist at bone and endometrium

increased risk of endometrial cancer, hot flashes, venous thrombosis (avoid long periods of immobility)

14

Raloxifen

Osteoporosis, reduces risk of breast cancer

Estrogen antagonist at breast and endometrium but agonist at bone

NO increased risk of endometrial cancer, hot flashes, venous thrombosis (avoid long periods of immobility)

15

Clomiphene

Stimulation of ovulation

Partial agonist at estrogen receptors

Hot flashes

Multiple births

16

Danazol

Endometriosis (not preferred), severe fibrocystic breath disease

Inhibits ovarian steroid synthesis, binds androgen, progesterone and glucocorticoid receptor

Wt. gain, edema, decrease breast size, acne, oily skin, increased hair growth, deepened voice

17

Anastrazole

Breast Cancer

Aromatase inhibitor, decreased estrogen synthesis

Nausea, weakness, hot flashes, osteoporosis

18

Fulvestrant

Breast Cancer

estrogen R antagonist that downregulates and degrades the receptor

nausea, weakness, hot flashes

19

Mifeprestone (RU-486)

Abortion, postcoital contraception, Cushings

Progesterone and glucocorticoid antagonist

Prolonged bleeding, vomiting, diarrhea, abdominal pain

Used w/ prostaglandin E1

20

Allendronate

Biphosphonate derivative used in the treatment of osteoporosis (not a sex hormone derivative)