Anemia

Question 1

Causes of decreased production of RBC x2

Question 2

Causes of ineffective erythropoiesis x5

Question 3

Causes of red cell aphasia x6

Question 4

Causes of iron deficiency anemia x3

Question 4

What is red cell aplasia

Question 5

Daily requirement for iron in infants

Question 6

Causes of RBC destruction x6

Question 7

Causes of blood loss x3

Question 8

How does JIA cause anemia

Question 9

Causes of microcytic anemia x3

Question 10

Which micronutrient helps with iron absorption

Question 11

Immune causes of RBC destruction x2

Question 12

Causes of normocytic anemia without bone marrow failure

Question 13

Causes of bone marrow failure resulting in normocytic anemia

Question 14

Diagnostic clues for hemolysis x5

Question 16

Vaccines needed before splenectomy x3 and life long prophylactic drug x1

Answer 16

Meningitis
Hemophilus influenza
Streptococcus pneumoniae

Penicillin prophylaxis

Question 17

Clinical features of hereditary spherocytosis x5

Question 18

Proteins in for RBC membrane x3

Answer 18

Spectrin
Ankyrin
Band 3

Question 19

Function of G6PD enzymes

Answer 19

Prevent oxidative damage to RBC

Question 20

Drugs inducing hemolysis in G6PD Deficiency x5

Question 21

Signs of acute hemolysis x3

Answer 21

Pallor
Jaundice
Dark urine

Question 22

Pathophysiology of sicke cell disease

Question 23

Triggers of vasooclussive crisis x5

Question 24

Long term problems of SCD x5

Question 25

Describe hyposplenism and autosplenectomy in SCD

Answer 25

Reduced splenic function due to spleen infarction and chronic sickling Autosplenectomy- infarction, scarring causes atrophy of the spleen

Question 26

Clinical manifestations of SCD x5

Question 27

Prophylaxis in SCD x3

Answer 27

Penicillin Folic acid Hydroxyurea

Question 28

Management of acute crisis in SCD x5

Answer 28

Fluids Oxygen Pain control Antibiotic cover Exchange transfusion

Question 29

Indications for exchange transfusion in SCD x3

Answer 29

Stroke Priaprism Acute chest syndrome

Question 30

Describe B thalassemia and its types x2

Answer 30

Reduced production of HbA due to mutations on the B globin gene 1. B thalassemia major- no HbA production 2. B thalassemia intermedia- some HbA production

Question 31

Manifestation of extramedullary hemopoiesis x2

Answer 31

Hepatosplenomegaly Bone marrow expansion

Question 32

Complications of chronic iron overload x5 and organs affected

Question 33

Causes of anemia of prematurity x4

Question 34

Acquirec causes of bone marrow failure x4

Answer 34

Hepatic viruses Chemotherapy Sulphonamides Toxins