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Flashcards in Anesthetics Deck (21):
0

Alveolar concentration required to eliminate the response to a standardized painful stimulus in 50% of patients
Best measure of potency

Minimum Alveolar Concentration

1

Incomplete anesthetic; rapid onset and recovery
MAC >100

Drug?

Nitrous Oxide

2

Anesthetic with very slow onset and recovery
MAC 0.16

Methoxyflurane

3

Anaesthetic that is contraindicated in reactive airways due to risk for bronchoconstriction

Desflurane

4

Facilitate GABA-mediated inhibition
Anesthesia for minor surgery and dental procedures, balanced anesthesia for major surgery
SE: Megaloblastic anemia, Euphoria
Drug with lowest potency (Highest MAC), least cardiotoxicity among inhalational anesthetic
Additive CNS depression with opioids and sedative-hypnotics

Drug, Class

Nitrous Oxide, GA (Inhalational)

5

Facilitate GABA-mediated inhibition
For GA
SE: Bronchospasm (pulmonary irritant)
Additive CNS depression with opioids and sedative-hypnotics
LUNGS
Drug, Class

Desflurane, GA (Inhalational)

6

Pungent Smelling Inhalational Anesthetic

Desflurane

7

Facilitate GABA-mediated inhibition
For GA
SE: Peripheral vasodilation, renal insufficiency from Compound A
Additive CNS depression with opioids and sedative-hypnotics
KIDNEY
Drug, Class

Sevoflurane, GA (Inhalational)

8

Sweet Smelling Inhalational Anesthetic

Sevoflurane

9

Facilitate GABA-mediated inhibition
For GA
SE: Catecholamine-induced arrhythmia, peripheral vasodilation, Coronary-Steal Syndrome
Additive CNS depression with opioids and sedative-hypnotics
HEART
Drug, Class

Isoflurane, GA (Inhalational)

10

Redistribution of blood flow from diseased to normal areas

Coronary Steal Syndrome

11

Facilitate GABA mediated inhibition
For GA
SE: Spike and wave activity, muscle twitching, breath-holding, renal insufficiency
Additive CNS depression with opioids and sedative-hypnotics
Drug, Class

Enflurane, GA (Inhalational)

12

Facilitate GABA mediated inhibition
For GA
SE: Catecholamine induced arrhythmia, Myocardial depression, Postop hepatitis
Additive CNS depression with opioids and sedative-hypnotics
Drug, Class

Halothane, GA (Inhalational)

14

Facilitate GABA mediated inhibition
For GA
SE: Renal Insufficiency
Highest potency and lowest MAC (very slow onset and recovery)
Additive CNS depression with opioids and sedative-hypnotics
Drug, Class

Methoxyflurane, GA (Inhalational)

15

Ultrashort acting barbiturate, IV anesthetic
Increases duration of Chloride channel opening
Drug for anesthesia induction, increased ICP
SE: higher likelihood of dependence than benzodiazepines
Additive CNS effects with ethanol
Potent indicer of CYP450

Drug?

Thiopental
(Methohexital, Thiamylal)

16

Short acting benzodiazepine, IV anesthetic
Increases frequency of chloride channel opening
Drug for acute anxiety, anesthesia induction, preop sedation
SE: anterograde amnesia, unwanted daytime sedation, rebound insomnia/anxiety
Additive CNS depression with alcohol
Antidote is Flumenazil
Drug?

Midazolam
(Brotizolam, Triazolam, Oxazepam, Etizolam)

17

Blocks excitation by glutamate at NMDA receptors
Drug for dissociative amnesia
SE: HPN, increased ICP, Emergence delirium (can be pretreated with benzodiazepines)

Drug, Class?

Ketamine, GA (Intravenous)

18

Modulates GABAa receptors containing Beta 3 subunits
Drug for GA especially in pxs with limited cardiac or respiratory reserve
SE: Adrenocortical suppression
Minimal effects on CV and Respi Fxns
No analgesic properties

Drug, Class?

Etomidate, GA (Intravenous)

19

Interacts with Mu receptor and Kappa receptor for endogenous opioid peptides
Drug for GA
SE: Respiratory depression
Antidote is Naloxone

Drug?

Fentanyl

20

10000x stronger than morphine

Fentanyl

21

Blocks Na channels
For GA, Prolonged sedation, Pre-op sedation
SE: Bradycardia, hypotension
Milk of Amnesia
Additive Effect with Sedative-Hypnotic Drugs
WOF: Airway, Dec in BP

Drug, Class?

Propofol, GA (Intravenous)
(Fospropofol)