Angina - Pharm lecture

Question 1

5 major risk factors for angina

Answer 1

1. dyslipidemia
2. diabetes
3. family hx of heart conditions
4. smoking
5. hypertension

Question 2

Definition of stable angina

Answer 2

angina/chest pain upon exertion which is alleviated with rest

Question 3

therapeutic objectives for treating angina

Answer 3

1. amelioration of anginal symptoms + improved angina-free exertion capacity
2. prevention or reduction of subsequent MI

Question 4

which type of calcium channel blocker is used to treat hypertension?

Answer 4

dihydropyridines, preferentially target blood vessels

Question 5

which type of calcium channel blocker is used to treat the heart ? for angina

Answer 5

non-dihydropyridines - they preferentially target the heart

Question 6

why is GTN used only for short term treatment?

Answer 6

you can quickly develop tolerance, but its better than beta/calcium channel blockers as GTN as its sublingual and therefore is faster-acting.

Question 7

Why are beta blockers/ca channel blockers used chronically?

Answer 7

you do not develop tolerance

Question 8

why is propanalol a top 3 beta blocker

Answer 8

its not treating angina (bisoprolol is more common), but it crosses the blood-brain barrier so its used to treat anxiety

Question 9

how does decreased liver enzymes due to age alter drug efficacy?

Answer 9

drug effectiveness generally is increased