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Flashcards in Anifungals Deck (31):
0

SE of amphotericin B

Nephrotoxicity (RTA), Note: aminoglycosides-ATN
Infusion reaction

2

Flucytosine is accumulated in fungal cells by the action of _ and converted by _ to _ which inhibits _

Permease; cytosine deaminase; 5-FU; thimidylate synthase

3

Binds ergosterol in fungal membrane forming artificial pores

Amphotericin B
Nystatin

5

Use of flucytosine

Cryptococcosis
Systemic candida
Chromoblastomycosis

6

For salvage therapy for invasive aspergillosis

Caspofungin

7

Accumulated in fungal cells by the action of permease and converted by cytosine deaminase to 5-FU which inhibits thimidylate synthase

Flucytosine

8

Limited to topical use because of ustemic toxicity

Ketoconazole
Clotrimazole

9

Fungistatic

Flucytosine
Azoles
Capsofungin

10

Treatment for Madura foot

Flucytosine

11

Inhibit fungal CYP450 dependent enzymes blocking ergosterol synthesis

Azoles

12

Uses of ketoconazole

Chronic mucocutanrous candidiasis
Dermatophytosis

13

Potent CYP450 inhibitor

Ketoconazole

15

Interferes with microtubule function, inhibiting sythesis and polymerization of nucleic acids

Griseofulvin

16

For treatment and prophylaxis of cryptococcal meningitis

Fluconazole

17

Narrow antifungal spectrum

Ketoconazole

18

Available in swish and swallow preparation

Nytstatin

19

Uses of fluconazole

Candidiasis
Coccidioidomycosis
Cryptococcal meningitis

20

Inhibits B glucan sunhase decreasing bacterial cell wall synthesis

Caspofungin

21

Use of griseofulvin

Dermatophytosis

22

Griseofulvin is contraidicated in _

Porphyria

24

Potent CYP450 inducer

Griseofulvin

25

Minimal mucocutaneous absorption

Nystatin

26

Use of terbinafine

Dermatophytosis
Onychomycosis

27

Accumulates in keratin

Griseofulvin
Terbinafine

28

Contraindicated in porphyria

Griseofulvin

29

Use of clotrimazole

Mucocutaneos candidiasis
Dermatophytosis
Seborrheic dermatitis
Ptyriasis versicolor

30

SE of nystatin

Nephrotoxicity

32

Use of nystatin

Candidiasis

38

Squalene oxidase inhibitor

Terbinafine

40

Fungicidal

Amphotericin B
Nystatin
Terbinafine

45

Pyrimidine antimetabolite

Flucytosine