anitpsychotics

Question 1

بسم الله الرحمن الرحيم
______________
BLOCKING …….receptors in ……………. system improve positive symptoms of schziophrenia

Answer 1

D2 receptors in Mesolimbic system

Question 2

blocking ….receptotrs in ,,,system imprves negative symptoms of schziphrenia

Answer 2

5HT2 receptors in mesocortical system

Question 3

Thoiridiazine black box warning

Answer 3

Arryhtmia
incresing QT interval

Question 4

Typical antipsychcotics should be used cautiosly in ?

Answer 4

Cardiac + Epiliptic patients

Question 5

Cholestaic jaundice + Corneal deposits CC
occurs in ?

Answer 5

Typical antipshycotics

Question 6

Blockage of D2 receptors

Answer 6

MCBH
1-Mesolimbic
2-CTZ anitemetic antihiccup
________________________
1-Basal ganglia
-2Hypothalamus + pituirary

Question 7

First line for akathesia ?

Answer 7

Propranolol

Question 8

Dystonia + Parkinsonism of Extrapyramidal side effects of D2 blockade treated by ?

Answer 8

Anticholinergics
Benzotropine

Question 9

EPS ?

Answer 9

ADPT
Akathesia
Dystonia
Parkinsonism
Tardive dyskinesia

Question 10

Neuroleptic malignant hyperthermia
mention symptoms + tratment

Answer 10

symptoms MHT
Muscle rigidity + Hyperthermia Hypertension + Tachycardia
Treatment = 3DB
Discontinue antipsychotic + Diazepam and dantrolene as muscle releaxnt to improve hyperthermia + Bromocriptine increasing dopamine

Question 11

1-contraidicated in Elderly + cardiac ?
2-Contraindicated in Parkinsonism perfered in cardiac ?

Answer 11

1-Chlorpromazine low potency
2-Halopridol high ptency

Question 12

Fluoxetine and paroxetine CYP 450
Interacts with

Answer 12

antipscyhotics

Question 13

IMI in agitation ?

Answer 13

Halopridol

Question 14

Atypical antipsychotics has less extrapyramidal side effects + Hyperprolactenimeia except>?

Answer 14

Respridone !

Question 15

antipsychotics of choice in parkinsonism ?

Answer 15

Clozapine + Quitapine

Question 16

Resistant Schizphrnia
Reseistant psychosis ?

Answer 16

Colzapine

Question 17

Agranulocytosis
مهم جدا جدا جدا جدا

Answer 17

Clozapine also with ?
antiepiliptic carabmazebine

Question 18

Side effects of clozapine

Answer 18

ISA
Insulin resistance
Seizure + nocturnal salivation
Agranulocytosis

Question 19

Side effects of clozapine

Answer 19

ISA
Insulin resistance
Seizure + nocturnal salivation
Agranulocytosis

Question 20

Galactorrhea
Gynecomastia
Increased QT interval ?

Answer 20

Repsirdone

Question 21

Characteristic for Olanzopine ?

Answer 21

Increasing BOdy weight

Question 22

Used in parkinsoisnm
Highly sedative
less EPS ?

Answer 22

qUITAPINE

Question 23

Antipsychotic with EPS
Perfered in children for cognition
Perferred in Obeses
but problem is >? Akathesia

Answer 23

Arpiprazole

Question 24

agitation

Answer 24

halpridol

Question 25

antiemetic anti hiccup ?

Answer 25

Chlorpromazine

Question 26

Autism ?

Answer 26

Respridone + Arpiprazole

Question 27

Lithium

Answer 27

mood stabilizer Anti manic anti derpessant anti suicidal

Question 28

Mention adverse effects and precuations of Lithium

Answer 28

CNS fINE tremors GIT NVDA if converted to Coarse tremors and increased Git symptoms =Warning signs of toxicity ____________________________ Renal : Nephrotic diabetes inspidus Antagonizing ADH Renal tubular damage so : Monitor kideny functiosn ________________ Hypothyoidism so monitos throyroid _____________________________

Question 29

Why Lithium is toxic drug ?

Answer 29

narro theraputic index and Long T1/2 with cumulative effects so Monitoring level and Adjusting doses is Obligatory ! Decreased excretion of Li due to? Na depletion by diuretics Renal dysfunction or due to old age

Question 30

Lithium is ...elminated so good in .... impariment so need dose adjustment in ?

Answer 30

Renally eleminated Heaptic impairment so need dose adjsutment in > renal dysfunction

Question 30

Why Lithium is toxic drug ?

Answer 30

narro theraputic index and Long T1/2 with cumulative effects so Monitoring level and Adjusting doses is Obligatory ! Decreased excretion of Li due to? Na depletion by diuretics Renal dysfunction or due to old age

Question 31

Most effective in lithium toxicity ?

Answer 31

Hemodialysis

Question 32

الحمدلله