ANS Drugs Block 1 Flashcards Preview

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Flashcards in ANS Drugs Block 1 Deck (116):
1

physiological NT; no therapeutic use

ACh

2

diagnose bronchial asthma & COPD

Methacholine (Muscarinic activity) directly activates cholinoreceptor

3

postoperative ileus & urinary retention

bethanechol (M3)

4

Carbachol 1. use 2. N or M

1. Glaucoma 2. N & M

5

Pilocarpine use

Glaucoma & Sjorgens syndrome & diagnose CFTR, induces sweat test directly activates M3

6

physostigmine use

REVERSIBLE INHIBITOR used to treat glaucoma

7

rivastigmine

tx alzheimers

8

neostigmine use

short duration; used treat myasthenia graves; reverse competitive blockade at NMJ

9

pyridostigmine use

long-term use; used treat myasthenia graves; reverse competitive blockade at NMJ

10

used to diagnose m. gravis

edrophonium

11

donepezil

tx alzheimers

12

ecothiophate

irreversible inhibitor used to treat glaucoma

13

homatropine

antimuscarinic used as mydriatic in refractive testing, uveitis, iritis

14

tacrine

tx alzheimers

15

biperidine

drug-induced parkinsons

16

antimuscarinic used as mydriatic in refractive testing, uveitis, iritis

homatropine, tropicamide, cyclopentolate

17

treatment for OP poisoning

atropine & 2-PAM

18

motion sickness

scopolamine

19

drug-induced parkinsons

benztropine, biperidine, trihexphenidyl

20

cyclopentolate

antimuscarinic used as mydriatic in refractive testing, uveitis, iritis

21

ipratropium

bronchial asthma

22

succinylcholine

depolarizing NMJ blocker used as skeletal muscle relaxant during general anesthesia

23

tropicamide

antimuscarinic used as mydriatic in refractive testing, uveitis, iritis

24

benztropine

drug-induced parkinsons

25

oxybutynin

urinary urgency

26

glocypyrolate

cystitis

27

ganglion blockers

hexamethonium & mecamylamine

28

pancuronium

competitive NMJ blocker used as skeletal muscle relaxant during general anesthesia

29

2-PAM

used with atropine in OP poisoning; breaks irreversible AChE inhibitor bond-->reactivates AChE

30

trihexphenidyl

drug-induced parkinsons

31

vecuronium

competitive NMJ blocker used as skeletal muscle relaxant during general anesthesia

32

epinephrine uses

1. with LA- prolong duration 2. cardiac arrest 3. glaucoma 4. anaphylaxis

33

epinephrine adverse effects

1. HTN 2. angina 3. cardiac arrhythmia

34

d-tubocurarine

competitive NMJ blocker used as skeletal muscle relaxant during general anesthesia

35

NE use

short-term hypotensive emergency

36

drugs used to treat BPH

alpha 1 blockers: prazosin, terazosin, tamsulosin (alpha 1A)

37

Isoproterenol adverse effects

tachycardia

38

isoproterenol uses

1. bronchial asthma 2. cardiac arrest 3. heart block

39

alpha 1 blockers

prazosin, terazosin, tamsulosin (alpha 1A)

40

drug used to treat cariogenic shock

dopamine or dobutamine

41

phenylephrine use

short-term hypotensive emergency

42

clonidine use

HTN

43

alpha-methyldopa use

HTN

44

clonidine adverse effects

1. sedation 2. abrupt withdrawal-->rebound HTN

45

alpha-methyldopa adverse effects

1. sedation 2. abrupt withdrawal-->rebound HTN

46

adverse effects of ephedrine & pseudoephedrine

tachyphylaxis

47

prazosin use

1. BPH 2. mild to moderate HTN

48

oxymetazoline & xylometazoline use

nasal decongestant--rhinitis, hay fever

49

cocaine a) MOA b) adverse effects

a) blocks reuptake b) 1. tachycardia 2. HTN 3. mydriasis

50

drugs used to treat ADHD & Narcolepsy

dextroampheramine, methylphenidate, dextroamphetamine

51

albuterol use & adverse effects

a) 1. bronchial asthma 2. premature labor b) skeletal muscle tremors

52

terbutaline use

a) 1. bronchial asthma 2. premature labor b) skeletal muscle tremors

53

prazosin: type of drug

alpha 1 blocker

54

prazosin: effect

1. improves urinary symptoms in BPH 2. decrease TPR--> decrease BP

55

alpha blockers

phenoxybenzamine & phentholamine

56

prazosin adverse effects

1. postural hypotension 2. minimal reflex tachycardia

57

ritodrine use

a) 1. bronchial asthma 2. premature labor b) skeletal muscle tremors

58

terazosin: type of drug

alpha 1 blocker

59

terazosin: effect

1. improves urinary symptoms in BPH 2. decrease TPR--> decrease BP

60

terazosin: use

1. BPH 2. mild to moderate HTN

61

terazosin: adverse effects

1. postural hypotension 2. minimal reflex tachycardia

62

-osin

alpha 1 blocker

63

-amine

alpha 1 & 2 blocker

64

tamsulosin: type of drug

alpha 1A blocker

65

tamsulosin: effect

1. improves urinary symptoms in BPH 2. decrease TPR--> decrease BP

66

tamsulosin: use

1. BPH 2. mild to moderate HTN

67

tamsulosin: adverse effects

1. postural hypotension 2. minimal reflex tachycardia

68

alpha 1 blocker a. effects b. use c. adverse effects

a) 1. improves urinary symptoms in BPH 2. decrease TPR--> decrease BP b) 1. BPH 2. mild to moderate HTN c) 1. postural hypotension 2. minimal reflex tachycardia

69

phenoxybenzamine: type of drug

non-selective alpha blocker

70

phenoxybenzamine: effects & use

1. decrease TPR --> decrease BP 2. HTN of pheochromocytoma

71

drugs used to treat HTN of pheochromocytoma

non-selective alpha blockers 1. phenoxybenzamine 2. phentolamine

72

phenoxybenzamine: adverse effects

1. postural hypotension 2. reflex tachycardia

73

phentolamine: adverse effects

1. postural hypotension 2. reflex tachycardia

74

1. postural hypotension 2. reflex tachycardia

side effects of alpha blockers

75

phentolamine: effects & use

1. decrease TPR --> decrease BP 2. HTN of pheochromocytoma

76

phentolamine: type of drug

non-selective alpha blocker

77

non-selective alpha blocker effects

decrease TPR --> decrease BP

78

effects of selective alpha 1 blockers

1. improves urinary symptoms in BPH 2. decrease TPR--> decrease BP

79

adverse effects of beta 2 stimulants

skeletal muscle tremors

80

use of selective beta 2 stimulants

1. bronchial asthma 2. premature labor

81

propranolol: type of drug

non-selective beta blocker

82

non-selective beta blockers

1. propranolol 2. nadolol 3. timolol 4. pindolol 5. sotalol

83

nadolol: type of drug

non-selective beta blocker

84

timolol: type of drug

non-selective beta blocker

85

pindolol: type of drug

non-selective beta blocker; partial agonist*****

86

sotalol: type of drug

non-selective beta blocker

87

propranolol: effects

1. decrease TPR-->decrease BP 2. decrease AV conduction 3. decrease cardiac work load

88

propranolol: uses

1. HTN 2. angina 3. performance anxiety 4. essential tremors 5. pheochromocytoma 6. cardiac arrhythmias 7. migraine prphylaxis 8. thyrotoxicosis

89

propranolol: adverse effects

1. bronchospasm--> contraindicated in COPD & bronchial asthma 2. can mask hypoglycemic symptoms

90

nadolol uses

1. HTN 2. angina *long duration of action

91

Timolol uses

decrease aqueous humor formation-->tx glaucoma due to blockade of beta 2 receptors located on ciliary processes

92

Pindolol uses

1. HTN 2. angina

93

sotalol effects & uses

blocks K+ channels-->tx cardiac arrhythmias

94

Labetolol use

1. HTN emergency 2. cardiac failure

95

Carvedilol use

1. HTN emergency 2. cardiac failure

96

Labetolol type of drug

alpha & beta blocker

97

Carvedilol

alpha & beta blocker

98

Cardioselective drugs (B1 > B2)

1. metoprolol 2. atenolol 3. acebutalol

99

metoprolol type of drug & use

B1>B2 1. safer beta blockers in asthmatics & diabetics

100

safer beta blockers in asthmatics & diabetics

1. metoprolol 2. atenolol 3. acebutalol all b1>b2

101

Esmolol

used to treat supra ventricular arrhythmias short plasma half life

102

Betaxolol

used to treat Glaucoma; decreased aqueous humor production due to blockade of beta 2 receptors located on ciliary processes long DOA

103

Cholinomimetics used to treat Glaucoma & MOA

1. carbachol 2. pilocarpine 3. physostigmine MOA: increased aqueous humor outflow (ciliary m contraction--> opens trabecular meshwork--> increased outflow through Schlemm's canal)

104

non-selective alpha agonist used to treat Glaucoma & MOA

Epinephrine MOA: 1. decreased aqueous humor production (via vasoconstriction & alpha 2 receptor activation) 2. increased aqueous humor outflow (through trabecular meshwork & uveoscleral route)

105

selective alpha 2 agonists used to treat glaucoma & MOA

1. apraclonidine 2. brimonidine MOA: decreased aqueous humor production ( due to activation of alpha-2 receptor located on ciliary process)

106

Glaucoma drugs that work to decrease aqueous humor production

1. non-selective alpha agonist Epinephrine 2. selective alpha2 agonists apraclinidine & brimonidine 3. beta blockers timolol & betaxolol 4. Diuretics: acetazolamide & Dorzolamide

107

beta blockers used to treat glaucoma & MOA

1. Timolol 2. Betaxolol MOA: decreased aqueous humor production (due to blockade of beta2 receptor located on ciliary process)

108

apraclonidine: 1. drug type 2. use 3. MOA

1. selective alpha 2 agonist 2. tx glaucoma 3. decreased aqueous humor production due to activation of alpha 2 receptor located on ciliary process

109

Brimonidine: 1. drug type 2. use 3. MOA

1. selective alpha 2 agonist 2. tx glaucoma 3. decreased aqueous humor production due to activation of alpha 2 receptor located on ciliary process

110

Carbachol: 1. drug type 2. use 3. MOA

1. cholinomimetic; directly acting 2. tx glaucoma 3. increased aqueous humor outflow (ciliary m contraction opens trabecular meshwork-->enhances outflow through Schlemm's canal

111

pilocarpine: 1. drug type 2. use 3. MOA

1. cholinomimetic; directly acting alkaloid 2. tx glaucoma 3. increased aqueous humor outflow (ciliary m contraction opens trabecular meshwork-->enhances outflow through Schlemm's canal

112

physostigmine: 1. drug type 2. use 3. MOA

1. cholinomimetic: reversible inhibitor; indirectly acting 2. tx glaucoma 3. increased aqueous humor outflow (ciliary m contraction opens trabecular meshwork-->enhances outflow through Schlemm's canal

113

mannitol use & MOA

Tx glaucoma by increasing aqueous humor outflow (due to the increased osmotic pressure of the plasma)

114

Latanoprost: 1. drug type 2. use 3. MOA

1. prostaglandin analog 2. Tx glaucoma 3. increased aqueous humor outflow through uveoscleral route

115

acetazolamide

diuretic used to treat glaucoma MOA: decreased aqueous humor production due to lack of HCO3-

116

dorzolamide

diuretic used to treat glaucoma MOA: decreased aqueous humor production due to lack of HCO3-