Flashcards in ANS Drugs Lecture Deck (31)
What are the Ca2+ channel blockers?
"pines"- these block L-type Ca2+ channels in smooth muscle only
What do Diltiazem and Verapamil do?
non-dihydropyridine ca2+ channel blockers that block L-type Ca2+ channels in CARDIAC and smooth muscle
Side effects of Ca2+ channel blockers?
What are some NO releasing drugs?
Side effects of Hydralazine?
-reversible lupus like syndrome
What are some drugs that open K+ channels?
What is an example of a D1 agonist? Mechanism?
Fenoldopam- vasodilates renal vessels and inhibits ACh release
What is a side effect of Diazoxide?
you also see inhibition of Ca2+ channels which can decrease insulin secretion and lead to hyperglycemia
How is angiotensinogen converted to angiotension I?
What drug blocks renin? Side effect?
What converts angiotension I to angiotension II?
What else does ACE do?
converts bradykinin to inactive metabolites
So what is a side effect of ACE inhibitors?
drug, irritating cough
What are the effects of angiotensin II?
What drugs prevent angiotensin II action?
ARBs- angiotension receptor blockers
cough is not a side effect
What are the ACEIs?
-end in 'prils'
Side effects of ACEIs?
Are ACEIs safe in pregnancy?
What are the ARBs?
end in 'sartan'
Side effects of ARBs?
-renal damage in preexisting disease
Are ARBs safe in pregnancy?
What are the recommended drugs for HTN in pregnancy?
can use Nefidipine, Labetolol, Metoprolol
What drugs are contraindicated in pregnancy?
What are the recommended drugs for HTN in diabetes?
What drugs are contraindicated in HTN with diabetes?
BB (high dose)
What are the recommended drugs for HTN in HF?
What drugs are contraindicated in HF?
BB (high dose), verapamil, diltiazem
What are the recommended drugs for HTN in COPD/asthma?
What drugs are contraindicated in COPD/asthma?
BBs (non selective high dose), ACEIs