ANS Drugs Lecture Flashcards Preview

Cardio Week 1 > ANS Drugs Lecture > Flashcards

Flashcards in ANS Drugs Lecture Deck (31):
1

What are the Ca2+ channel blockers?

"pines"- these block L-type Ca2+ channels in smooth muscle only

2

What do Diltiazem and Verapamil do?

non-dihydropyridine ca2+ channel blockers that block L-type Ca2+ channels in CARDIAC and smooth muscle

3

Side effects of Ca2+ channel blockers?

-constipation
-edema
-bradycardia
-headache
-AV block

BEACH

4

What are some NO releasing drugs?

-Hydralazine
-Nitroprusside

5

Side effects of Hydralazine?

-reversible lupus like syndrome
-edema
-arteriolar dilation

READ

6

What are some drugs that open K+ channels?

-Minoxidil
-Diazoxide

7

What is an example of a D1 agonist? Mechanism?

Fenoldopam- vasodilates renal vessels and inhibits ACh release

8

What is a side effect of Diazoxide?

you also see inhibition of Ca2+ channels which can decrease insulin secretion and lead to hyperglycemia

9

How is angiotensinogen converted to angiotension I?

renin

10

What drug blocks renin? Side effect?

Alskiren; hyperkalemia

11

What converts angiotension I to angiotension II?

ACE

12

What else does ACE do?

converts bradykinin to inactive metabolites

13

So what is a side effect of ACE inhibitors?

drug, irritating cough

14

What are the effects of angiotensin II?

-vasoconstriction
-aldosterone secretion

15

What drugs prevent angiotensin II action?

ARBs- angiotension receptor blockers

cough is not a side effect

16

What are the ACEIs?

-end in 'prils'

17

Side effects of ACEIs?

-cough
-hyperkalemia
-angioedema
-renal damage

CRAH

18

Are ACEIs safe in pregnancy?

No, teratogenic

19

What are the ARBs?

end in 'sartan'

20

Side effects of ARBs?

-renal damage in preexisting disease
-hyperkalemia

21

Are ARBs safe in pregnancy?

No

22

What are the recommended drugs for HTN in pregnancy?

a-methyldopa
Hydralazine

can use Nefidipine, Labetolol, Metoprolol

23

What drugs are contraindicated in pregnancy?

ACEIs, ARBs

24

What are the recommended drugs for HTN in diabetes?

ACEIs, ARBs

25

What drugs are contraindicated in HTN with diabetes?

BB (high dose)

26

What are the recommended drugs for HTN in HF?

ACEIs

27

What drugs are contraindicated in HF?

BB (high dose), verapamil, diltiazem

28

What are the recommended drugs for HTN in COPD/asthma?

CCBs

29

What drugs are contraindicated in COPD/asthma?

BBs (non selective high dose), ACEIs

30

What are the recommended drugs for HTN in CKD?

ACEIs, ARBs

31

What are the recommended drugs for HTN in BPH?

a-blockers