Flashcards in Anterior Horn Cell and Peripheral Nerve Disorders Deck (21):
Emotional dysregulation (such as inappropriate laughing or crying) can be a symptom of _______-motor neuron disorders.
What are type I and type II muscle fibers?
Type I: aerobic, mitochondria-rich, slow twitch
Type II: anaerobic, mitochondria-poor, fast twitch
Twitching (fasciculation) is associated with ____________ disorders.
anterior horn (such as ALS)
What motor neurons does ALS affect?
Both upper and lower
Explain the etiology of the term amyotrophic lateral sclerosis.
Lateral sclerosis = the lateral parts of the spinal cord develop sclerosis
Amyotrophic = the muscles fail to grow because of lack of input
What is the mean age-of-onset of ALS?
What percent of ALS is inherited?
There is only one drug that has been shown to improve the prognosis of those with ALS. What is it?
Riluzole – this just slows the progression
What are some treatments for spasticity?
Phenytoin, benzodiazepams, quinine, dantrolene, and gabapentin – all relaxants or anticonvulsants
Most neuropathies affect the _________ muscles first.
Most myopathies affect the _________ muscles first.
Defects in the PMP-22 gene can lead to two disorders, depending on the mutation: __________.
deletion leads to hereditary neuropathy with pressure palsy (HNPP) and duplication leads to Charcot-Marie-Tooth
All motor neuron, neuromuscular junction, and muscle diseases have no loss of ___________; if there is loss of that, it suggests a nerve-root disorder or peripheral nerve disease.
How can you differentiate disuse-related atrophy from neuromuscular atrophy?
Neuromuscular atrophy leads to a greater degree of weakness.
Myopathy leads to loss of a _________, while neuromuscular disorders lead to loss of ___________.
muscle fiber within a motor unit; loss of a whole motor unit
There is no loss of ___________ in ALS.
The most common type of diabetic neuropathy is ____________.
Autonomic dysfunction can occur in which kind of neuropathy?
What is a sign, found on the hands, that is symptomatic of ALS?
Thenar and hypothenar atrophy
What are the treatment options for Charcot-Marie-Tooth?
No medications, only PT, OT, and surgery