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Flashcards in Anti-Coagulation with AF Deck (12)
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1

What must be done prior to commensing one of the new anticoagulants?

Assess renal function

2

What is the target INR for stroke reduction in AF?

2-3

3

What is the HAS-BLED score for? What does each letter stand for?

Risk of bleeding while on warfarin

H - Hypertension

A - abnormal liver or kidney function

S - Strokes in the past

B - Bleeding in the past

L - Labile INR

E - Elderly age 

D - Drugs (NSAIDs/anti-platelets) and Alcohol

 Each receives 1 point

3

What is the CHADS2 score cutoff for commensing anti-coagulation?

Greater than or equal to 2

4

What are apixaban and rivaroxaban?

Factor Xa inhibitors

6

How long does warfarin take to establish it's anti-coagulatory effects?

Many days

6

When are the newer anti-coagulants indicated over warfarin?

If INR control is not possible to achieve - for reasons other than poor compliance

If the patient is unable to undergo INR monitoring

 

8

What is dabigatran?

A direct thrombin inhibitor

9

What factors act to interfere with warfarin action?

Dietary vitamin K

Hepatic enzyme profiles that vary between patients

Drug-drug interactions

Drug-disease interactions

10

How is dabigatran excreted? What are the implications?

Renally

Contraindicated if creatinine clearance is <30

11

Which node is ablated in AF?

AV

12

When is restoration of sinus rhythm considered in AF?

When the patient is very symptomatic and doesn't response to rate control