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Flashcards in Anti Folate Deck (39):
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Structural analogs of paba

Sulfonamides

1

Sulfonamides moa

Inbit dihydropteroate SYNTHASE

2

Oral, absorbable short acting sulfonamide

Sulfisoxazole

3

Sulfisoxazole use

used almost exclusively for UTI

4

Oral, absorbable intermediate acting sulfonamide

Sulfadiazine
Sulfamethoxazole

5

Oral, absorbable long acting sulfonamide

Sulfadoxine

6

Oral, non absorbable sulfonamide

Sulfasalazine

7

Topical sulfonamides

Sodium sulfacetamide
Malenide acetate
Silver sulfadiazine

8

Sulfadiazine + pyrimethamine + folinic acid

Toxoplasmosis
Leishmaniasis

9

Sulfadoxine + pyrimethamine

Malaria tx

10

Trimethoprim + sulfamethoxazole

DOC for pneumocystis jiroveci pneumonia
Toxoplasmosis
Nocardiosis

11

Sulfasalazine use

Not absorbed, acts locally, so use in GI lesions like ulcerative colitis and enteritis

12

Topical tx for bacterial conjunctivitis and trachoma

Sodium sulfacetamide

13

Topical sulfonamide that inhibits carbonic anhydrase causing met acidosis

Mafenide acetate

14

Topical sulfonamide for burn wounds

Silver sulfadiazine

15

Causes stevens johnson syndrome

Sulfonamides

16

Other adrs of sulfonamides

Crystalluria, hematuria, obstruction
Hematopoiesis influence
Kernicterus
Bleeding with warfarin interaction

17

Combination ratio of trimethoprim and sulfonamides

1:5

less tri needed because it is more lipid soluble

18

Sequential synergistic blockade exhibited by

Trimethoprims when it follows sulfonamides

19

Synthetic fluorinated analogs of nalidixic acid

Fluoroquinolones

20

Fluoroquinolones MOA

Inhibits bacterial topoisomerase II (dna gyrase) and topoisomerase IV (separation of replicated dna into daughter cells)

21

First gen fluoroquinolone

Nalidixic acid

22

Second gen fluoroquinolone

Norfloxacin

23

Third gen fluoroquinolone

Ciprofloxacin
Levofloxacin
Ofloxacin

24

Fourth gen fluoroquinolone

Moxifloxacin

25

Fluoroquinolone with 3 hr half life

Norfloxacin
Ciprofloxacin

26

Fluoroquinolone with 10 hr half life

Perfloxacin
Fleroxacin

27

Fluoroquinolone with long half life

Sparfloxacin
Levofloxacin
Moxifloxacin
Trovafloxacin

28

L isomer of ofloxacin

Levofloxacin

29

Fluoroquinolone pulled out bc lots if cardiovascular adrs

Gatifloxacin

30

DOC px and tx anthrax

Ciprofloxacin

31

Fluoroquinolone for gonococcal and chlamydia

Ciprofloxacin and levofloxacin

32

Fluoroquinolone for drug resistant tb and atypical mycobacterium

Cipro
Levo
Moxi

33

Respiratory quinolones

Levo
Gati
Gemi
Moxi

34

Gatifloxacin adrs

Qt prolongation, torsades de point
Hyper and hypogly
Inhibit collagen synthesis, tendinitis

35

Protozoan infections with metronidazole as DOC

Entamoeba histolytica
Giardia lambia
Trichomonas vaginalis

36

Anaerobic infections with metronidazole as DOC

Bacteroides fragilis
Clostridium difficile
Giardia vaginalis

37

With the ff adrs - metallic taste, brown black urine, disulfiram like

Metronidazole

38

Antibiotics for h pylori ulcers

Amoxicillin
Clarithromycin
Tetracycline
Metronidazole