Anti thrombosis and anti platelet drugs Flashcards Preview

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Flashcards in Anti thrombosis and anti platelet drugs Deck (10):
1

What is atherosclerosis?

Damage to the endothelium and recruitment of foamy macrophages rrich in cholesterol which then results in plaque formation.

2

What happens when the plaque ruptures in atherosclerosis?

Platelet recruitment and activation

3

What is the target in preventing arterial thrombus?

Platelets

4

How does aspirin work?

Inhibits Cyclo oxygenase which is necessary to produce thromboxane A2

5

What does cycloxoygenase do?

Necessary to produce thromboxane

6

What are the side effects of aspirin?

1. Bleeding
2. Blocks production of prostoglandins
3. GI ulceration
4. Bronchospasm

7

What kind of drug is Clopidogrel?

ADP receptor antagonist

8

In what condition is aspirin contraindicated?

Asthmas (Aspirin causes bronchospasm)

9

What kind of drug s dipyridamole?

Phosphodiesterase inhibitor which reduces production of cAMP

10

How long do you have to stop antiplatelet agents for before an operation?

7 days