Flashcards in Anti thrombosis and anti platelet drugs Deck (10):
What is atherosclerosis?
Damage to the endothelium and recruitment of foamy macrophages rrich in cholesterol which then results in plaque formation.
What happens when the plaque ruptures in atherosclerosis?
Platelet recruitment and activation
What is the target in preventing arterial thrombus?
How does aspirin work?
Inhibits Cyclo oxygenase which is necessary to produce thromboxane A2
What does cycloxoygenase do?
Necessary to produce thromboxane
What are the side effects of aspirin?
2. Blocks production of prostoglandins
3. GI ulceration
What kind of drug is Clopidogrel?
ADP receptor antagonist
In what condition is aspirin contraindicated?
Asthmas (Aspirin causes bronchospasm)
What kind of drug s dipyridamole?
Phosphodiesterase inhibitor which reduces production of cAMP