Antiarrhythmic

Question 1

2nd class antiarrhythmics are

Answer 1

1st and 2nd gen BAB

Question 2

4th class antiarrhythmic are

Answer 2

Verapamil and diltiazem (non dihydropiridine calcium channel blockers)

Question 3

1class antiarrhythmic are

Answer 3

Procainamide1A,1B- lidocaine, 1C-ethacizine,propafenon, flecainid

Question 4

Prcainamide has

Answer 4

cholinolytic activity

Question 5

Ethacizine has class

Answer 5

4 property

Question 6

Propafenon has both

Answer 6

Class 2 and 4 property

Question 7

Flecainid has

Answer 7

Class 3 property

Question 8

Class 3 antiarrhythmic agents are

Answer 8

Amiodarone, sotalol, vernakalant

Question 9

Amiodarone class 3 has properties of

Answer 9

Class 1a,2 and 4

Question 10

Sotalol class 3 has alo property of

Answer 10

Class 2

Question 11

Vernakalant class 3 has also property of class

Answer 11

1b

Question 12

Non classified antiarrhythmic agents are

Answer 12

Magnesium sulphate, Atropine, Digoxin, epinephrine

Question 13

Phase 0 depolarization of SA node and AV nodeis provided by

Answer 13

Calcium influx

Question 14

Phase 3of repolarization is provided by

Answer 14

K outflux

Question 15

Phase 4 of slow depolarisation is provided by

Answer 15

Na influx through HCN channel and calcium influx

Question 16

Arrythmia is defined as

Answer 16

Change in location of impulse origin ,change in HR and change in rhythm, conduction disturbance

Question 17

Norm HR

Answer 17

55 to 80

Question 18

Batmotropy

Answer 18

Ability to excite in response to stimulus

Question 19

Dromotropy

Answer 19

Ability to conduct from one cell to other

Question 20

Hemodynamics means

Answer 20

Providing rhythm and frequency control

Question 21

Class 2 and 4 of antiarrhythmic inhibits

Answer 21

Phase 0 and 4 calcium influx in SA and AV

Question 22

Class 3 inhibits

Answer 22

K outflux in phase 3 of CM

Question 23

Class 1b and class 1c inhibits

Answer 23

Phase 0 Na influx in CM

Question 24

Class 1a inhibits

Answer 24

CM in phase 0 Na influx and in phase 3,K outflux

Question 25

Except 1b all others are used in

Answer 25

Supraventricular arrythmia

Question 26

Except class 4 and vernakalant all others are used in

Answer 26

Ventricular arrythmia

Question 27

For all 1a in ECG

Answer 27

Increase in QRS duration and QT increase

Question 28

For all 1b class in ECG

Answer 28

Qt decrease

Question 29

For. Al class 1c in ECG

Answer 29

QRS duration increase

Question 30

1a and 1c has more affinity to

Answer 30

Open na channel than inactivated

Question 31

Dissociation kinetics of drugs in na channels

Answer 31

1b faster than 1a faster than 1c

Question 32

SE of Procainamide1A

Answer 32

Hypotension, lupus erythematous syndrome,TdP

Question 33

Class 1 a has

Answer 33

Pro arrythmia effect(exacerbate or create new arrythmia)

Question 34

Lidocaine doesn't change QRS duration, because of

Answer 34

Fast DK

Question 35

Lidocaine use

Answer 35

VA

Question 36

Lidocaine has first pass metabolism,it has SE

Answer 36

CNS toxicity

Question 37

Class 1 c use

Answer 37

SVA including Afib

Question 38

SE of class 1 c

Answer 38

Heart failure

Question 39

Class 3 effect on ECG

Answer 39

QT interwal prolongation

Question 40

Amiodarone changes in ECG

Answer 40

Prolonged QRS,RR I,PRi,,QT i

Question 41

Use of amiodarone

Answer 41

SVA(including Afib),VA

Question 42

SE of amiodarone

Answer 42

Hypo or hyperthyroidism, pneumofibrosis, photo toxicity and hepatotoxicity, blue skin pigmentation (smurf skin), corneal deposition, rarely Tdp

Question 43

Amiodarone is structurally similar to

Answer 43

Thyroxine

Question 44

Amiodarone has long T1)2of

Answer 44

50 days and large distribution volumes

Question 45

Amiodarone which is lipid soluble accumulates in

Answer 45

Liver ,muscle,lung,skin,fat

Question 46

Acute overdose of amiodarone cause

Answer 46

Bradyarrythmia and hypotension

Question 47

Chronic overdose of amiodarone cause

Answer 47

Bradyarrythmia, ventricular arrythmia, pulmonary toxicity, hypothyroidism etc

Question 48

Treatment of amiodarone toxicity

Answer 48

QRS prolongation, bradyarrythmia and hypotension can be treated by sodium bicarbonate (reverse cardiac depression),Treat Torsades de pointes with magnesium

Question 49

Use of vernakalant

Answer 49

Acute Afib

Question 50

SE of vernakalant

Answer 50

Hypotension and bradycardia

Question 51

Use of BAB in arrythmia

Answer 51

Frequency control of SVA and VA treatment

Question 52

Magnesium sulphate action

Answer 52

Reduction of calcium inflow in ventricular cardiomyocyte

Question 53

Magnesium sulphate use

Answer 53

TdP treatment

Question 54

Atropine use

Answer 54

Sinus bradycardia and AV node block

Question 55

Epinephrine use

Answer 55

CPR

Question 56

Digoxin use

Answer 56

SVA