Antibacterial Agents 2: Cell-Wall Synthesis Inhibitors Flashcards Preview

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Flashcards in Antibacterial Agents 2: Cell-Wall Synthesis Inhibitors Deck (29):
1

What are the 4 classes/types of cell wall inhibitor drugs?

1. Vancomycin
2. Penicillin
3. Cephalosporin
4. Carbapenems

"Vice President Cell Crushers"

*BEFORE COMPLETING THE REST OF THESE NOTE CARDS, LOOK AT THE ANTIBIOTIC SPECTRUM THAT FRENCH POSTED ONLINE. FOCUS ON PENICILLINS, CEPHALOS and VANC.

2


What is B-lactamase and why is it important?

It is a bacterial enzyme that breaks down many penicillin drugs and causes resistance

3

Which drug is used to treat Penicillin resistant bacterias (beta-lactamase or penicillinase).

Dicloxacillin

4

Most cephalosporins act like _________ plus a ______

amoxicillin + a beta-lactamase inhibitor)

5

Know the ~20 drugs and their general targets (ie cell wall inhibition, protein inhibition, DNA inhibition, etc)

According to lecture 2.

6

True or False: Most cephalosporins are not broken down by B lactamase.

True.

Most Cephalosporins

7

How is amoxicillin administered?

PO (orally) only

8

How is Penicillin V administered?

PO Only

9

Which penicillin drugs are administered IV only?

Piperacillin*
Penicillin G
Ticarcillin

*most important

10

How is dicloxicillin administered?

Oral Only

11

How are Penicillins eliminated? Cephalosporins?

Both Renal

They are not a DQ-CRIMES drug

Cephalosporins are very similar to penicillins

12

Which Penicillin is VERY acid resistant?

Penicillin V

13

Which kind of organisms does amoxicillin cover against?

Gram + and -

Its an Extended Spectrum Antibiotic

14

Which kind of organisms does Piperacillin cover against?

1. All Gram + and -
2. Anaerobic infections (caused by B. fragilis)
3. Pseudomonas

15

What is Clavulanic Acid?

Its a B-lactamase inhibitor that is frequently combined with Amoxicillin (together known as augmentin)

16

How do you cover a MSSA (S. Aureus) infection?

With Dicloxacillin
OR
Amox/Clav or Pip/Taz

(Clav and Taz are B-lac inhibitors)

17

What is unique about the distribution of 3rd generation cephalosporins? Name them.

-They penetrate the Brain real well.

CefTriaxone
CefTazidime

(Cef-T stands for Cef-Three)

18

First generation Cephalosporins can be thought of as a ___________ + a __________.

Amoxicilin + Clavulanic Acid

19

TEST QUESTION:
If you develop a rash or anaphylaxis (type 1 response) with use of penicillin, it is okay to take a cephalosporin.

FALSE

DONT DO IT.

Use Macrolides instead.

20

Whats a major difference between Amoxicilin and Cephalexin (1st Gen)?

Amox is susceptible to B-Lactamase

21

Vancomycin inhibits which stage of protein wall synthesis?

Stage 2 and is effective against systemic MRSA and C. Dif.

22

When treating MRSA, how is Vancomycin administered?

IV

23

When treating C. Dif, how is Vancomycin administered?

PO

24

What are the 3 adverse reactions to Vancomycin?

1. Redman Syndrome infusion related)
2. Nephrotoxicity
3. Ototoxicity

25

An infection of MSSA can be treated with ALL penicillins and Cephalosporins EXCEPT:

Penecillin and straight amoxicillin.

If extended covereage amoxicillin is used (amox+clav) then it works.

26

Which Penicillins and Cephalosporins cover Gram Negative Rod bacteria?

Amoxicillin (all forms)
Piperacillin + Tazo (Pip/taz)

All cephalosporins

27

Which of the following would best treat a pseudomonas infection? more than 1 possible
Pip/taz
Amox/Clav
Amox
Cephalexin (1st)
Ceftriaxone (3rd)

Pip/Taz**** Most important

Ceftriaxone (3rd)

28

Which of the following would best treat an anerobic infection (B. Fragilis)? more than 1 possible
Pip/taz
Amox/Clav
Amox
Cephalexin (1st)
Ceftriaxone (3rd)

Pip/Taz

Amox/Clav

29

Which of the following would best treat an gram negative cocci infection? more than 1 possible
Pip/taz
Amox/Clav
Amox
Cephalexin (1st)
Ceftriaxone (3rd)

Ceftriaxone (3rd)

Gram - cocci =N. Gonorrhoeae