Antibacterials 4 Flashcards Preview

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Flashcards in Antibacterials 4 Deck (26)
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Natural penicillins

Pen g
Pen vk

1

Which natural pen has oral bioavailability?

Pen vk

2

For
Bacterial meningitis
Syphilis
Pneumonia
Leptospirosis

Pen G

3

Only for
Pneumonia (S. pneumonia) and leptospirosis
Can't treat syphilis, meningitis or H. Influenzae infections

Pen VK

4

Penicillase resistant pens

Oxacillin
Cloxacillin

5

Anti-staphylococcal pens

Oxacillin
Cloxacillin

6

Oxacillin and cloxacillin no activity on

Gram neg,
anaerobes,
enterococci

7

Which one has inc GI absorption and reduce hepatic clearance, oxacillin or cloxacillin?

Cloxacillin

8

Purely oral antistaph pen

Cloxacillin

9

Aminopens

Amoxicillin
Ampicillin

10

Aminopens ampicillin and amoxicillin with activity on

Gram positives L monocytogenes, S viridans
Gram negatives E coli, N. meningitides, P mirabilis, Shigella, Salmonella
Anaerobic Clostridium Peptococcus

11

Usually administered with clavulanic acid

Amoxicillin

12

Most commonly used aminopen, oral

Amoxicillin

13

Semisynthetic pen alpha benzyl derivative of pen G, well distributed in body and CSF, broad spectrum antibiotic

Ampicillin

14

For
Otitis media
LRTi
Acute bacterial sinusitis
Pyelonephritis

Amoxicillin

15

Basic structure of penicillin

Thiazolidine ring attached to beta lactam ring

16

Repository forms of penicillin

Benzathine and procaine

17

Moa penicillins

Structural analog of D-ala-D-ala, binds to active site of PBPs

18

Reaction inhibited by penicillins

Transpeptidation reaction

19

Resistance against penicillins

Inactivation by beta lactamase
Mod of PBPs
Impaired penetration esp in gram negs, thick cell wall
Efflux

20

Absorption of penicillins and food

Impaired, take 1 h before or 2 h after a meal

21

Painful when done with pen g

IM

22

Can raise bloodlevels of penicillins

Probenecid

23

Nafcillin clearance

Biliary excretion

24

Partial biliary excretion

Oxacillin
Cloxacillin
Dicloxacillin

25

Penicillin main excretion

Renal
10% glomerular filtration
90% tubular secretion