Flashcards in Antibacterials 7 Deck (32)
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Binding site for clindamycin identical with
Chloramphenicol and macrolides
1
50s inhibitor, interferes with formation of initiation complexes, aminoacyl translocation
Clindamycin
2
Penetrates well into abscesses
Clindamycin
3
Percent of protein bound clindamycin
90%
4
Alternative for staph and strep for those allergic to beta lactams, alternative to cotrimoxazole for jiroveci and toxoplasmosis
Clindamycin
5
Recommended rather than erythromycin for endocarditis prophylaxis for those undergoing certain dental procedures
Clindamycin
6
Combined with clindamycin for jiroveci pneumonia
Primaquine
7
Important quinolones are...
Synthetic fluorinated derivatives of nalidixic acid
8
Quinolones moa
Blocks topo ii and topo iv
9
Prevents relaxation of positively coiled DNA
DNA gyrase/ Topo II
10
Interferes with separation of replicated chromosomal DNA into respective daughter cells during cell division
Topo IV
11
Quinolone, 1st gen
Nalidixic acid
12
Quinolone with narrowest spectrum
Nalidixic acid
13
2nd gen quinolones
Ciprofloxacin
Ofloxacin
14
Best for pseudomonas
Ciprofloxacin
Ofloxacin
15
3rd gen quinolones
Levofloxacin
Moxifloxacin
Gatilfloxacin
16
Quinolone, problems with blood sugar of diabetic patients
Gatilfloxacin
17
Hepatotoxic quinolone
Trovafloxacin
18
Effective in UTIs even if caused by mdr bacteria like pseudomonas
Fluoroquinolones except moxifloxacin
19
Drug of choice for treatment and prophylaxis of anthrax
Ciprofloxacin
20
Effective for gonococcal inf, chlamydial urethritis, cervicitis
Ciprofloxacin and levofloxacin
21
Severe GIT inf, UTI, MDR typhoid, severe RTIs due to gram negs, osteomyelitis/septicemia
Ciprofloxacin
22
Most specific fluoroquinolone against P aeruginosa
Ciprofloxacin
23
Vancomycin moa
Inhibits cell wall synthesis
24
Vancomycin difference from beta lactams
Binds to d al d ala not an analogue
25
Vancomycin is synergistic with
Streptomycin
Gentamicin
26
First line therapy for C difficile colitis
Metronidazole
27
Poorly absorbed in the gi tract but used for treatment of colitis due to C difficle, not first line
Vancomycin
28
MRSA
Plus combined with cefotaxime, ceftriaxone, or rifampin for meningitis caused by penicillin resistant pneumococcus
Vancomycin
29
