Antibacterials 7

Question 0

50s inhibitor, interferes with formation of initiation complexes, aminoacyl translocation

Answer 0

Clindamycin

Question 1

Binding site for clindamycin identical with

Answer 1

Chloramphenicol and macrolides

Question 2

Penetrates well into abscesses

Answer 2

Clindamycin

Question 3

Percent of protein bound clindamycin

Answer 3

90%

Question 4

Alternative for staph and strep for those allergic to beta lactams, alternative to cotrimoxazole for jiroveci and toxoplasmosis

Answer 4

Clindamycin

Question 5

Recommended rather than erythromycin for endocarditis prophylaxis for those undergoing certain dental procedures

Answer 5

Clindamycin

Question 6

Combined with clindamycin for jiroveci pneumonia

Answer 6

Primaquine

Question 7

Important quinolones are…

Answer 7

Synthetic fluorinated derivatives of nalidixic acid

Question 8

Quinolones moa

Answer 8

Blocks topo ii and topo iv

Question 9

Prevents relaxation of positively coiled DNA

Answer 9

DNA gyrase/ Topo II

Question 10

Interferes with separation of replicated chromosomal DNA into respective daughter cells during cell division

Answer 10

Topo IV

Question 11

Quinolone, 1st gen

Answer 11

Nalidixic acid

Question 12

Quinolone with narrowest spectrum

Answer 12

Nalidixic acid

Question 13

2nd gen quinolones

Answer 13

Ciprofloxacin

Ofloxacin

Question 14

Best for pseudomonas

Answer 14

Ciprofloxacin

Ofloxacin

Question 15

3rd gen quinolones

Answer 15

Levofloxacin
Moxifloxacin
Gatilfloxacin

Question 16

Quinolone, problems with blood sugar of diabetic patients

Answer 16

Gatilfloxacin

Question 17

Hepatotoxic quinolone

Answer 17

Trovafloxacin

Question 18

Effective in UTIs even if caused by mdr bacteria like pseudomonas

Answer 18

Fluoroquinolones except moxifloxacin

Question 19

Drug of choice for treatment and prophylaxis of anthrax

Answer 19

Ciprofloxacin

Question 20

Effective for gonococcal inf, chlamydial urethritis, cervicitis

Answer 20

Ciprofloxacin and levofloxacin

Question 21

Severe GIT inf, UTI, MDR typhoid, severe RTIs due to gram negs, osteomyelitis/septicemia

Answer 21

Ciprofloxacin

Question 22

Most specific fluoroquinolone against P aeruginosa

Answer 22

Ciprofloxacin

Question 23

Vancomycin moa

Answer 23

Inhibits cell wall synthesis

Question 24

Vancomycin difference from beta lactams

Answer 24

Binds to d al d ala not an analogue

Question 25

Vancomycin is synergistic with

Answer 25

Streptomycin | Gentamicin

Question 26

First line therapy for C difficile colitis

Answer 26

Metronidazole

Question 27

Poorly absorbed in the gi tract but used for treatment of colitis due to C difficle, not first line

Answer 27

Vancomycin

Question 28

MRSA | Plus combined with cefotaxime, ceftriaxone, or rifampin for meningitis caused by penicillin resistant pneumococcus

Answer 28

Vancomycin

Question 29

Vancomycin for gram pos and neg?

Answer 29

NO! Gram positive only

Question 30

Vancomycin adverse effects

Answer 30

Red man syndrome Ototoxicity Nephrotoxicity

Question 31

Vancomycin can kill all Gram pos except

Answer 31

Flavobacterium