Antibacterials 7 Flashcards Preview

Ther 201 3rd Exam > Antibacterials 7 > Flashcards

Flashcards in Antibacterials 7 Deck (32)
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0

Binding site for clindamycin identical with

Chloramphenicol and macrolides

1

50s inhibitor, interferes with formation of initiation complexes, aminoacyl translocation

Clindamycin

2

Penetrates well into abscesses

Clindamycin

3

Percent of protein bound clindamycin

90%

4

Alternative for staph and strep for those allergic to beta lactams, alternative to cotrimoxazole for jiroveci and toxoplasmosis

Clindamycin

5

Recommended rather than erythromycin for endocarditis prophylaxis for those undergoing certain dental procedures

Clindamycin

6

Combined with clindamycin for jiroveci pneumonia

Primaquine

7

Important quinolones are...

Synthetic fluorinated derivatives of nalidixic acid

8

Quinolones moa

Blocks topo ii and topo iv

9

Prevents relaxation of positively coiled DNA

DNA gyrase/ Topo II

10

Interferes with separation of replicated chromosomal DNA into respective daughter cells during cell division

Topo IV

11

Quinolone, 1st gen

Nalidixic acid

12

Quinolone with narrowest spectrum

Nalidixic acid

13

2nd gen quinolones

Ciprofloxacin
Ofloxacin

14

Best for pseudomonas

Ciprofloxacin
Ofloxacin

15

3rd gen quinolones

Levofloxacin
Moxifloxacin
Gatilfloxacin

16

Quinolone, problems with blood sugar of diabetic patients

Gatilfloxacin

17

Hepatotoxic quinolone

Trovafloxacin

18

Effective in UTIs even if caused by mdr bacteria like pseudomonas

Fluoroquinolones except moxifloxacin

19

Drug of choice for treatment and prophylaxis of anthrax

Ciprofloxacin

20

Effective for gonococcal inf, chlamydial urethritis, cervicitis

Ciprofloxacin and levofloxacin

21

Severe GIT inf, UTI, MDR typhoid, severe RTIs due to gram negs, osteomyelitis/septicemia

Ciprofloxacin

22

Most specific fluoroquinolone against P aeruginosa

Ciprofloxacin

23

Vancomycin moa

Inhibits cell wall synthesis

24

Vancomycin difference from beta lactams

Binds to d al d ala not an analogue

25

Vancomycin is synergistic with

Streptomycin
Gentamicin

26

First line therapy for C difficile colitis

Metronidazole

27

Poorly absorbed in the gi tract but used for treatment of colitis due to C difficle, not first line

Vancomycin

28

MRSA
Plus combined with cefotaxime, ceftriaxone, or rifampin for meningitis caused by penicillin resistant pneumococcus

Vancomycin

29

Vancomycin for gram pos and neg?

NO! Gram positive only